Phema: An overview for biomedical applications

Mina Zare, Ashkan Bigham, Mohamad Zare, Hongrong Luo, Erfan Rezvani Ghomi, Seeram Ramakrishna

Forskningsoutput: TidskriftsbidragÖversiktsartikelPeer review

Sammanfattning

Poly(2-hydroxyethyl methacrylate) (pHEMA) as a biomaterial with excellent biocompati-bility and cytocompatibility elicits a minimal immunological response from host tissue making it desirable for different biomedical applications. This article seeks to provide an in-depth overview of the properties and biomedical applications of pHEMA for bone tissue regeneration, wound healing, cancer therapy (stimuli and non-stimuli responsive systems), and ophthalmic applications (contact lenses and ocular drug delivery). As this polymer has been widely applied in ophthalmic applications, a specific consideration has been devoted to this field. Pure pHEMA does not possess antimicrobial properties and the site where the biomedical device is employed may be susceptible to microbial infections. Therefore, antimicrobial strategies such as the use of silver nanoparticles, antibiotics, and antimicrobial agents can be utilized to protect against infections. Therefore, the antimicrobial strategies besides the drug delivery applications of pHEMA were covered. With continuous research and advancement in science and technology, the outlook of pHEMA is promising as it will most certainly be utilized in more biomedical applications in the near future. The aim of this review was to bring together state-of-the-art research on pHEMA and their applications.

Originalspråkengelska
Artikelnummer6376
TidskriftInternational Journal of Molecular Sciences
Volym22
Nummer12
ISSN1661-6596
DOI
StatusPublicerad - 2 juni 2021
Externt publiceradJa
MoE-publikationstypA2 Granska artikel i en vetenskaplig tidskrift

Bibliografisk information

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Vetenskapsgrenar

  • 317 Farmaci

Citera det här