Porous silicon nanoparticles for nanomedicine

preparation and biomedical applications

Forskningsoutput: TidskriftsbidragÖversiktsartikelVetenskapligPeer review

Sammanfattning

The research on porous silicon (PSi) materials for biomedical applications has expanded greatly since the early studies of Leigh Canham more than 25 years ago. Currently, PSi nanoparticles are receiving growing attention from the scientific biomedical community. These nanostructured materials have emerged as promising multifunctional and versatile platforms for nanomedicine in drug delivery, diagnostics and therapy. The outstanding properties of PSi, including excellent in vivo biocompatibility and biodegradability, have led to many applications of PSi for delivery of therapeutic agents. In this review, we highlight current advances and recent efforts on PSi nanoparticles regarding the production properties, efficient drug delivery, multidrug delivery, permeation across biological barriers, biosafety and in vivo tracking for biomedical applications. The constant boost on successful preclinical in vivo data reported so far makes this the ‘golden age’ for PSi, which is expected to finally be translated into the clinic in the near future.
Originalspråkengelska
TidskriftNanomedicine
Volym9
Utgåva4
Sidor (från-till)535-554
Antal sidor20
ISSN1743-5889
DOI
StatusPublicerad - 2014
MoE-publikationstypA2 Granska artikel i en vetenskaplig tidskrift

Vetenskapsgrenar

  • 317 Farmaci

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title = "Porous silicon nanoparticles for nanomedicine: preparation and biomedical applications",
abstract = "The research on porous silicon (PSi) materials for biomedical applications has expanded greatly since the early studies of Leigh Canham more than 25 years ago. Currently, PSi nanoparticles are receiving growing attention from the scientific biomedical community. These nanostructured materials have emerged as promising multifunctional and versatile platforms for nanomedicine in drug delivery, diagnostics and therapy. The outstanding properties of PSi, including excellent in vivo biocompatibility and biodegradability, have led to many applications of PSi for delivery of therapeutic agents. In this review, we highlight current advances and recent efforts on PSi nanoparticles regarding the production properties, efficient drug delivery, multidrug delivery, permeation across biological barriers, biosafety and in vivo tracking for biomedical applications. The constant boost on successful preclinical in vivo data reported so far makes this the ‘golden age’ for PSi, which is expected to finally be translated into the clinic in the near future.",
keywords = "317 Pharmacy, mesoporous silicon nanoparticles",
author = "Santos, {H{\'e}lder A.} and Ermei M{\"a}kil{\"a} and Anu Airaksinen and Bimbo, {Luis Maria} and Jouni Hirvonen",
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language = "English",
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pages = "535--554",
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Porous silicon nanoparticles for nanomedicine : preparation and biomedical applications. / Santos, Hélder A.; Mäkilä, Ermei; Airaksinen, Anu; Bimbo, Luis Maria; Hirvonen, Jouni .

I: Nanomedicine, Vol. 9, Nr. 4, 2014, s. 535-554.

Forskningsoutput: TidskriftsbidragÖversiktsartikelVetenskapligPeer review

TY - JOUR

T1 - Porous silicon nanoparticles for nanomedicine

T2 - preparation and biomedical applications

AU - Santos, Hélder A.

AU - Mäkilä, Ermei

AU - Airaksinen, Anu

AU - Bimbo, Luis Maria

AU - Hirvonen, Jouni

PY - 2014

Y1 - 2014

N2 - The research on porous silicon (PSi) materials for biomedical applications has expanded greatly since the early studies of Leigh Canham more than 25 years ago. Currently, PSi nanoparticles are receiving growing attention from the scientific biomedical community. These nanostructured materials have emerged as promising multifunctional and versatile platforms for nanomedicine in drug delivery, diagnostics and therapy. The outstanding properties of PSi, including excellent in vivo biocompatibility and biodegradability, have led to many applications of PSi for delivery of therapeutic agents. In this review, we highlight current advances and recent efforts on PSi nanoparticles regarding the production properties, efficient drug delivery, multidrug delivery, permeation across biological barriers, biosafety and in vivo tracking for biomedical applications. The constant boost on successful preclinical in vivo data reported so far makes this the ‘golden age’ for PSi, which is expected to finally be translated into the clinic in the near future.

AB - The research on porous silicon (PSi) materials for biomedical applications has expanded greatly since the early studies of Leigh Canham more than 25 years ago. Currently, PSi nanoparticles are receiving growing attention from the scientific biomedical community. These nanostructured materials have emerged as promising multifunctional and versatile platforms for nanomedicine in drug delivery, diagnostics and therapy. The outstanding properties of PSi, including excellent in vivo biocompatibility and biodegradability, have led to many applications of PSi for delivery of therapeutic agents. In this review, we highlight current advances and recent efforts on PSi nanoparticles regarding the production properties, efficient drug delivery, multidrug delivery, permeation across biological barriers, biosafety and in vivo tracking for biomedical applications. The constant boost on successful preclinical in vivo data reported so far makes this the ‘golden age’ for PSi, which is expected to finally be translated into the clinic in the near future.

KW - 317 Pharmacy

KW - mesoporous silicon nanoparticles

U2 - 10.2217/nnm.13.223

DO - 10.2217/nnm.13.223

M3 - Review Article

VL - 9

SP - 535

EP - 554

JO - Nanomedicine

JF - Nanomedicine

SN - 1743-5889

IS - 4

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