Disclosed are compds. of formula I, their prepn., and use in preventing or treating a bacterial infection. Compds. of I [wherein R is , (un)substituted heterocycloalkyl and (un)substituted aryl; X is H and substituted aminothiazolyl; n = 0, 1, 2, 3 or 4; M = H or cation] and stereoisomers, pharmaceutically acceptable salt thereof, are claimed and exemplified. Example compd. II.bul.TFA was prepd. by a multistep procedure (prepn. given). Candidate compds. of I were evaluated for antibacterial activity (data given). [on SciFinder(R)]
|Utgivningsår||21 dec 2017|
|Status||Publicerad - 21 dec 2017|
|MoE-publikationstyp||H1 Beviljat patent|
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Patel, P. A., & ., P. V. J. B. R. P. M. V. (2017). Preparation of N-(alkanoyl)-7-oxo-6-sulfooxy-1,6-diazabicyclo[3.2.1]octane-2-carbonylhydrazide derivatives and their use as antibacterial agents. (Patentnr. WO 2017216764 A1).