Profile of and risk factors for poststroke cognitive impairment in diverse ethno-regional groups

Jessica W Lo, John D Crawford, David W Desmond, Olivier Godefroy, Hanna Jokinen, Simin Mahinrad, Hee-Jon Bae, Jae-Sung Lim, Sebastian Köhler, Elles Douven, Julie Staals, Christopher Chen, Xin Xu, Eddie J Chong, Rufus O Akinyemi, Rajesh N Kalaria, Adesola Ogunniyi, Mélanie Barbay, Martine Roussel, Byung-Chul LeeVelandai K Srikanth, Christopher Moran, Nagaendran Kandiah, Russell J Chander, Behnam Sabayan, J Wouter Jukema, Susanna Melkas, Timo J Erkinjuntti, Henry Brodaty, Régis Bordet, Stéphanie Bombois, Hilde Hénon, Darren M Lipnicki, Nicole A Kochan, Perminder S Sachdev

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Sammanfattning

OBJECTIVE: To address the variability in prevalence estimates and inconsistencies in potential risk factors for poststroke cognitive impairment (PSCI) using a standardized approach and individual participant data (IPD) from international cohorts in the Stroke and Cognition Consortium (STROKOG) consortium.
METHODS: We harmonized data from 13 studies based in 8 countries. Neuropsychological test scores 2 to 6 months after stroke or TIA and appropriate normative data were used to calculate standardized cognitive domain scores. Domain-specific impairment was based on percentile cutoffs from normative groups, and associations between domain scores and risk factors were examined with 1-stage IPD meta-analysis.
RESULTS: In a combined sample of 3,146 participants admitted to hospital for stroke (97%) or TIA (3%), 44% were impaired in global cognition and 30% to 35% were impaired in individual domains 2 to 6 months after the index event. Diabetes mellitus and a history of stroke were strongly associated with poorer cognitive function after covariate adjustments; hypertension, smoking, and atrial fibrillation had weaker domain-specific associations. While there were no significant differences in domain impairment among ethnoracial groups, some interethnic differences were found in the effects of risk factors on cognition.
CONCLUSIONS: This study confirms the high prevalence of PSCI in diverse populations, highlights common risk factors, in particular diabetes mellitus, and points to ethnoracial differences that warrant attention in the development of prevention strategies.
Originalspråkengelska
TidskriftNeurology
Volym93
Utgåva24
Sidor (från-till)e2257-e2271
Antal sidor16
ISSN0028-3878
DOI
StatusPublicerad - dec 2019
MoE-publikationstypA1 Tidskriftsartikel-refererad

Vetenskapsgrenar

  • 3124 Neurologi och psykiatri
  • 515 Psykologi

Citera det här

Lo, J. W., Crawford, J. D., Desmond, D. W., Godefroy, O., Jokinen, H., Mahinrad, S., ... Sachdev, P. S. (2019). Profile of and risk factors for poststroke cognitive impairment in diverse ethno-regional groups. Neurology, 93(24), e2257-e2271. https://doi.org/10.1212/WNL.0000000000008612