Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacy

Isobella Honeyborne; Timothy D. McHugh; Iitu Kuittinen; Anna Cichonska; Dimitrios Evangelopoulos; Katharina Ronacher; Paul D. van Helden; Stephen H. Gillespie; Delmiro Fernandez-Reyes; Gerhard Walzl; Juho Rousu; Philip D. Butcher; Simon J. Waddell

doi:10.1186/s12916-016-0609-3

Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacy

Isobella Honeyborne, Timothy D. McHugh, Iitu Kuittinen, Anna Cichonska, Dimitrios Evangelopoulos, Katharina Ronacher, Paul D. van Helden, Stephen H. Gillespie, Delmiro Fernandez-Reyes, Gerhard Walzl, Juho Rousu, Philip D. Butcher, Simon J. Waddell

Institutet för molekylärmedicin i Finland

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

Originalspråk	engelska
Artikelnummer	68
Tidskrift	BMC Medicine
Volym	14
Antal sidor	13
ISSN	1741-7015
DOI	https://doi.org/10.1186/s12916-016-0609-3
Status	Publicerad - 7 apr. 2016
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

Vetenskapsgrenar

3111 Biomedicinska vetenskaper

Åtkomst av dokument

10.1186/s12916-016-0609-3

Profiling persistent tubercule bacilliSlutlig publicerad version, 2,94 MBLicens: CC BY

Citera det här

Honeyborne, I., McHugh, T. D., Kuittinen, I., Cichonska, A., Evangelopoulos, D., Ronacher, K., van Helden, P. D., Gillespie, S. H., Fernandez-Reyes, D., Walzl, G., Rousu, J., Butcher, P. D., & Waddell, S. J. (2016). Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacy. BMC Medicine, 14, [68]. https://doi.org/10.1186/s12916-016-0609-3

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title = "Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacy",

keywords = "Mycobacterium tuberculosis, Sputum, Transcriptional profiling, Predictive biomarker, Persistent infection, GENE-EXPRESSION DATA, MYCOBACTERIUM-TUBERCULOSIS, TRANSCRIPTIONAL ADAPTATION, PULMONARY TUBERCULOSIS, CULTURE CONVERSION, MACROPHAGES, METABOLISM, SELECTION, TIME, POPULATIONS, 3111 Biomedicine",

author = "Isobella Honeyborne and McHugh, {Timothy D.} and Iitu Kuittinen and Anna Cichonska and Dimitrios Evangelopoulos and Katharina Ronacher and {van Helden}, {Paul D.} and Gillespie, {Stephen H.} and Delmiro Fernandez-Reyes and Gerhard Walzl and Juho Rousu and Butcher, {Philip D.} and Waddell, {Simon J.}",

year = "2016",

month = apr,

day = "7",

doi = "10.1186/s12916-016-0609-3",

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T1 - Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacy

AU - Honeyborne, Isobella

AU - McHugh, Timothy D.

AU - Kuittinen, Iitu

AU - Cichonska, Anna

AU - Evangelopoulos, Dimitrios

AU - Ronacher, Katharina

AU - van Helden, Paul D.

AU - Gillespie, Stephen H.

AU - Fernandez-Reyes, Delmiro

AU - Walzl, Gerhard

AU - Rousu, Juho

AU - Butcher, Philip D.

AU - Waddell, Simon J.

PY - 2016/4/7

Y1 - 2016/4/7

KW - Mycobacterium tuberculosis

KW - Sputum

KW - Transcriptional profiling

KW - Predictive biomarker

KW - Persistent infection

KW - GENE-EXPRESSION DATA

KW - MYCOBACTERIUM-TUBERCULOSIS

KW - TRANSCRIPTIONAL ADAPTATION

KW - PULMONARY TUBERCULOSIS

KW - CULTURE CONVERSION

KW - MACROPHAGES

KW - METABOLISM

KW - SELECTION

KW - TIME

KW - POPULATIONS

KW - 3111 Biomedicine

U2 - 10.1186/s12916-016-0609-3

DO - 10.1186/s12916-016-0609-3

M3 - Article

VL - 14

JO - BMC Medicine

JF - BMC Medicine

SN - 1741-7015

M1 - 68

ER -