Prognostic Value and Changes of Auditory Brain Stem Response in Children With Bacterial Meningitis in Luanda, Angola

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Objective:To assess the role of single and repeated auditory brain stem response (ABR) in predicting mortality and severe neurological injury among children having bacterial meningitis (BM) in Luanda, Angola.Methods:The morphology of ABR traces of 221 children (aged 2?months to 12?years) from admission day was analyzed and compared with age-matched normative data. Absence and delay of traces were compared with mortality and mortality or severe neurological injury in subgroup analyses. Outcome was also evaluated with repeated ABR of 166 children based on presence or absence of responses at 80?dB nHL (normal hearing level) stimulation level.Results:Individually, the absence of typical ABR waveform did not signify poor outcome. At the group level, latencies and interpeak latencies (IPLs) were significantly prolonged among patients with BM in comparison with controls, and the prolongation correlated with higher mortality or severe neurological sequelae.Conclusions:We confirmed the effect of BM on neural conduction time in auditory pathway. However, ABR in similar settings seems not useful for individual prognostication, although at the group level, delayed latencies, IPLs, or both associated with poorer outcome.
Originalspråkengelska
Artikelnummer1179550618758648
TidskriftClinical medicine insights. Ear, nose and throat
Volym11
Antal sidor11
ISSN1179-5506
DOI
StatusPublicerad - 1 jan 2018
MoE-publikationstypA1 Tidskriftsartikel-refererad

Vetenskapsgrenar

  • 3123 Kvinno- och barnsjukdomar

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title = "Prognostic Value and Changes of Auditory Brain Stem Response in Children With Bacterial Meningitis in Luanda, Angola",
abstract = "Objective:To assess the role of single and repeated auditory brain stem response (ABR) in predicting mortality and severe neurological injury among children having bacterial meningitis (BM) in Luanda, Angola.Methods:The morphology of ABR traces of 221 children (aged 2?months to 12?years) from admission day was analyzed and compared with age-matched normative data. Absence and delay of traces were compared with mortality and mortality or severe neurological injury in subgroup analyses. Outcome was also evaluated with repeated ABR of 166 children based on presence or absence of responses at 80?dB nHL (normal hearing level) stimulation level.Results:Individually, the absence of typical ABR waveform did not signify poor outcome. At the group level, latencies and interpeak latencies (IPLs) were significantly prolonged among patients with BM in comparison with controls, and the prolongation correlated with higher mortality or severe neurological sequelae.Conclusions:We confirmed the effect of BM on neural conduction time in auditory pathway. However, ABR in similar settings seems not useful for individual prognostication, although at the group level, delayed latencies, IPLs, or both associated with poorer outcome.",
keywords = "3123 Gynaecology and paediatrics",
author = "Mariia Karppinen and Atte Sj{\"o}vall and Tuula Pelkonen and Luis Bernardino and Irmeli Roine and Anne Pitk{\"a}ranta and Aarnisalo, {Antti A} and P{\"a}ivi Nevalainen and Leena Lauronen",
year = "2018",
month = "1",
day = "1",
doi = "10.1177/1179550618758648",
language = "English",
volume = "11",
journal = "Clinical medicine insights. Ear, nose and throat",
issn = "1179-5506",
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TY - JOUR

T1 - Prognostic Value and Changes of Auditory Brain Stem Response in Children With Bacterial Meningitis in Luanda, Angola

AU - Karppinen, Mariia

AU - Sjövall, Atte

AU - Pelkonen, Tuula

AU - Bernardino, Luis

AU - Roine, Irmeli

AU - Pitkäranta, Anne

AU - Aarnisalo, Antti A

AU - Nevalainen, Päivi

AU - Lauronen, Leena

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Objective:To assess the role of single and repeated auditory brain stem response (ABR) in predicting mortality and severe neurological injury among children having bacterial meningitis (BM) in Luanda, Angola.Methods:The morphology of ABR traces of 221 children (aged 2?months to 12?years) from admission day was analyzed and compared with age-matched normative data. Absence and delay of traces were compared with mortality and mortality or severe neurological injury in subgroup analyses. Outcome was also evaluated with repeated ABR of 166 children based on presence or absence of responses at 80?dB nHL (normal hearing level) stimulation level.Results:Individually, the absence of typical ABR waveform did not signify poor outcome. At the group level, latencies and interpeak latencies (IPLs) were significantly prolonged among patients with BM in comparison with controls, and the prolongation correlated with higher mortality or severe neurological sequelae.Conclusions:We confirmed the effect of BM on neural conduction time in auditory pathway. However, ABR in similar settings seems not useful for individual prognostication, although at the group level, delayed latencies, IPLs, or both associated with poorer outcome.

AB - Objective:To assess the role of single and repeated auditory brain stem response (ABR) in predicting mortality and severe neurological injury among children having bacterial meningitis (BM) in Luanda, Angola.Methods:The morphology of ABR traces of 221 children (aged 2?months to 12?years) from admission day was analyzed and compared with age-matched normative data. Absence and delay of traces were compared with mortality and mortality or severe neurological injury in subgroup analyses. Outcome was also evaluated with repeated ABR of 166 children based on presence or absence of responses at 80?dB nHL (normal hearing level) stimulation level.Results:Individually, the absence of typical ABR waveform did not signify poor outcome. At the group level, latencies and interpeak latencies (IPLs) were significantly prolonged among patients with BM in comparison with controls, and the prolongation correlated with higher mortality or severe neurological sequelae.Conclusions:We confirmed the effect of BM on neural conduction time in auditory pathway. However, ABR in similar settings seems not useful for individual prognostication, although at the group level, delayed latencies, IPLs, or both associated with poorer outcome.

KW - 3123 Gynaecology and paediatrics

U2 - 10.1177/1179550618758648

DO - 10.1177/1179550618758648

M3 - Article

VL - 11

JO - Clinical medicine insights. Ear, nose and throat

JF - Clinical medicine insights. Ear, nose and throat

SN - 1179-5506

M1 - 1179550618758648

ER -