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Sammanfattning
Apteranthes europaea (Guss.) Murb. subsp. maroccana (Hook.f.) Plowes (A. europaea) is a medicinal plant widely used in traditional medicines to treat various diseases including hepatic pathogenesis. This study was conducted to evaluate the protective effect of chemically characterized polyphenol-rich fraction from A. europaea on carbon tetrachloride-induced liver injury in mice. The chemical characterization of A. europaea polyphenol-rich fraction was carried out using HPLC-DAD (high-performance liquid chromatography (HPLC) with a diode-array detector (DAD)). Carbon tetrachloride (CCl4) was used to induce liver injuries in mice as described in previous works. A polyphenol-rich fraction from A. europaea was used at a dose of 50 mg/Kg to study its hepatoprotective effect. Next, histopathological and biochemical alterations were investigated. The HPLC analysis revealed the presence of several phenolic compounds: gallic acid, methyl gallate, rutin, ferulic acid, and resorcinol. Regarding the mice treated with a polyphenol-rich fraction from A. europaea up to 50 mg/Kg and carbon tetrachloride, no significant biochemical nor histological alterations occurred in their liver; meanwhile, serious biochemical and histopathological changes were noted for liver recovered from the mice treated with carbon tetrachloride only. In conclusion, A. europaea extract is a promising source of hepatoprotective agents against toxic liver injury.
Originalspråk | engelska |
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Artikelnummer | 554 |
Tidskrift | Applied sciences (Basel) |
Volym | 11 |
Nummer | 2 |
Sidor (från-till) | 1-10 |
Antal sidor | 10 |
ISSN | 2076-3417 |
DOI | |
Status | Publicerad - jan. 2021 |
MoE-publikationstyp | A1 Tidskriftsartikel-refererad |
Vetenskapsgrenar
- 116 Kemi
Projekt
- 1 Slutfört
-
VAHVISTUS: Integrative development of smart drug-vector nanostructures for adaptive delivery to target cells
Grafov, A. (Projektledare)
01/03/2017 → 28/02/2022
Projekt: Forskningsprojekt