Proteostasis Modulators with Discriminating Taste

Ville Paavilainen; Jack Taunton

doi:10.1016/j.chembiol.2013.02.002

Proteostasis Modulators with Discriminating Taste

Forskningsoutput: Tidskriftsbidrag › Översiktsartikel › Peer review

Sammanfattning

Small molecules that perturb protein homeostasis are used as cancer therapeutics and as antibiotics to treat bacterial infections. In a recent issue of Cell, Kannan and colleagues describe an intriguing mechanism that enables ribosome-targeted macrolides to selectively remodel the bacterial proteome. This finding suggests the exciting possibility of targeting additional proteostasis regulators in a substrate-selective manner.

Originalspråk	engelska
Tidskrift	Chemistry & Biology
Volym	20
Nummer	2
Sidor (från-till)	144-145
Antal sidor	2
ISSN	1074-5521
DOI	https://doi.org/10.1016/j.chembiol.2013.02.002
Status	Publicerad - 2013
Externt publicerad	Ja
MoE-publikationstyp	A2 Granska artikel i en vetenskaplig tidskrift

Vetenskapsgrenar

1182 Biokemi, cell- och molekylärbiologi

Åtkomst av dokument

10.1016/j.chembiol.2013.02.002

Citera det här

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title = "Proteostasis Modulators with Discriminating Taste",

abstract = "Small molecules that perturb protein homeostasis are used as cancer therapeutics and as antibiotics to treat bacterial infections. In a recent issue of Cell, Kannan and colleagues describe an intriguing mechanism that enables ribosome-targeted macrolides to selectively remodel the bacterial proteome. This finding suggests the exciting possibility of targeting additional proteostasis regulators in a substrate-selective manner.",

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AB - Small molecules that perturb protein homeostasis are used as cancer therapeutics and as antibiotics to treat bacterial infections. In a recent issue of Cell, Kannan and colleagues describe an intriguing mechanism that enables ribosome-targeted macrolides to selectively remodel the bacterial proteome. This finding suggests the exciting possibility of targeting additional proteostasis regulators in a substrate-selective manner.

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DO - 10.1016/j.chembiol.2013.02.002

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