Pumilol, a Diterpenoid with a Rare Strobane Skeleton from Pinus pumila (Pinaceae)

Moses Langat, Andreas Helfenstein, Claire Horner, Päivi Tammela, Heikki Hokkanen, Denis Izotov, Dulcie Mulholland

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Sammanfattning

Pumilol (1), a strobane diterpenoid, reported herein for the first time, was isolated from the bark of Pinus pumila (Pall.) Regel (Siberian Dwarf Pine or Japanese Stone Pine), along with 17 known compounds including serratane triterpenoids, not previously reported from this species, and four ferulate derivatives. The absolute configuration of pumilolwas established using HR-ESI-MS, NMR, the DP4+ probabilities and by comparison of the experimental and calculated electronic circular dichroism (ECD) spectra. Labda-8(17),13-dien-15-oic acid (4), bornyl (E)-4-hydroxycinnamate (14) and bornyl (E)-ferulate (15) showed activity against S.aureus and/or E.faecalis with MIC90 values 12.5-50m.

Originalspråkengelska
Artikelnummere1800056
TidskriftChemistry & Biodiversity
Volym15
Utgåva10
Antal sidor7
ISSN1612-1872
DOI
StatusPublicerad - 3 jul 2018
MoE-publikationstypA1 Tidskriftsartikel-refererad

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