Quercetin-Based Modified Porous Silicon Nanoparticles for Enhanced Inhibition of Doxorubicin-Resistant Cancer Cells

Zehua Liu, Vimalkumar Balasubramanian, Chinmaya Bhat, Mikko Vahermo, Ermei Mäkilä, Marianna Kemell, Flavia Fontana, Agnė Janoniene, Vilma Petrikaite, Jarno Salonen, Jari Yli-Kauhaluoma, Jouni Hirvonen, Hongbo Zhang, Helder A. Santos

Forskningsoutput: TidskriftsbidragArtikelPeer review

Sammanfattning

One of the most challenging obstacle in nanoparticle’s surface modification is to achieve the concept that one ligand can accomplish multiple purposes. Upon such consideration, 3-aminopropoxy-linked quercetin (AmQu), a derivative of a natural flavonoid inspired by the structure of dopamine, is designed and subsequently used to modify the surface of thermally hydrocarbonized porous silicon (PSi) nanoparticles. This nanosystem inherits several advanced properties in a single carrier, including promoted anticancer efficiency, multiple drug resistance (MDR) reversing, stimuli-responsive drug release, drug release monitoring, and enhanced particle-cell interactions. The anti-cancer drug doxorubicin (DOX) is efficiently loaded into this nanosystem and released in a pH-dependent manner. AmQu also effectively quenches the fluorescence of the loaded DOX, thereby allowing the use of the nanosystem for monitoring the intracellular drug release. Furthermore, a synergistic effect with the presence of AmQu is observed in both normal MCF-7 and DOX-resistant MCF-7 breast cancer cells. Due to the similar structure as dopamine, AmQu may facilitate both the interaction and internalization of PSi into the cells. Overall, this PSi-based platform exhibits remarkable superiority in both multi-functionality and anti-cancer efficiency, making this nanovector a promising system for anti-MDR cancer treatment.
Originalspråkengelska
Artikelnummer1601009
TidskriftAdvanced Healthcare Materials
Volym6
Utgåva3
Antal sidor11
ISSN2192-2640
DOI
StatusPublicerad - 8 feb 2017
MoE-publikationstypA1 Tidskriftsartikel-refererad

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