Reconstructing functional networks in the human intestinal tract using synthetic microbiomes

Systems Biology • Nanobiotechnology

Sudarshan A Shetty, Hauke Smidt, Willem M de Vos

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Sammanfattning

The human intestinal tract harbors one of the most densely populated and open microbial ecosystems. The application of multi-omics approaches has provided insight into a wide array of complex interactions between the various groups of mainly anaerobic colonic microbes as well as the host–microbe dialogue. Integration of multi-omics techniques in cultivation based experiments that vary in complexity from monocultures to synthetic microbial communities identified key metabolic players in the trophic interactions as well as their ecological dynamics. A synergy between these approaches will be of utmost importance to reconstruct the functional interaction networks at the ecosystem level within the human intestinal microbiome. The improved understanding of microbiome functioning at ecosystem level will further aid in developing better predictive models and design of effective microbiome modulation strategies for health benefits.
Originalspråkengelska
TidskriftCurrent Opinion in Biotechnology
Volym58
Sidor (från-till)146-154
Antal sidor9
ISSN0958-1669
DOI
StatusPublicerad - 6 apr 2019
MoE-publikationstypA1 Tidskriftsartikel-refererad

Vetenskapsgrenar

  • 3111 Biomedicinska vetenskaper

Citera det här

@article{f81556f23d354a64927612c95096d602,
title = "Reconstructing functional networks in the human intestinal tract using synthetic microbiomes: Systems Biology • Nanobiotechnology",
abstract = "The human intestinal tract harbors one of the most densely populated and open microbial ecosystems. The application of multi-omics approaches has provided insight into a wide array of complex interactions between the various groups of mainly anaerobic colonic microbes as well as the host–microbe dialogue. Integration of multi-omics techniques in cultivation based experiments that vary in complexity from monocultures to synthetic microbial communities identified key metabolic players in the trophic interactions as well as their ecological dynamics. A synergy between these approaches will be of utmost importance to reconstruct the functional interaction networks at the ecosystem level within the human intestinal microbiome. The improved understanding of microbiome functioning at ecosystem level will further aid in developing better predictive models and design of effective microbiome modulation strategies for health benefits.",
keywords = "3111 Biomedicine",
author = "Shetty, {Sudarshan A} and Hauke Smidt and {de Vos}, {Willem M}",
year = "2019",
month = "4",
day = "6",
doi = "10.1016/j.copbio.2019.03.009",
language = "English",
volume = "58",
pages = "146--154",
journal = "Current Opinion in Biotechnology",
issn = "0958-1669",
publisher = "Current Biology",

}

Reconstructing functional networks in the human intestinal tract using synthetic microbiomes : Systems Biology • Nanobiotechnology. / Shetty, Sudarshan A; Smidt, Hauke; de Vos, Willem M.

I: Current Opinion in Biotechnology, Vol. 58, 06.04.2019, s. 146-154.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

TY - JOUR

T1 - Reconstructing functional networks in the human intestinal tract using synthetic microbiomes

T2 - Systems Biology • Nanobiotechnology

AU - Shetty, Sudarshan A

AU - Smidt, Hauke

AU - de Vos, Willem M

PY - 2019/4/6

Y1 - 2019/4/6

N2 - The human intestinal tract harbors one of the most densely populated and open microbial ecosystems. The application of multi-omics approaches has provided insight into a wide array of complex interactions between the various groups of mainly anaerobic colonic microbes as well as the host–microbe dialogue. Integration of multi-omics techniques in cultivation based experiments that vary in complexity from monocultures to synthetic microbial communities identified key metabolic players in the trophic interactions as well as their ecological dynamics. A synergy between these approaches will be of utmost importance to reconstruct the functional interaction networks at the ecosystem level within the human intestinal microbiome. The improved understanding of microbiome functioning at ecosystem level will further aid in developing better predictive models and design of effective microbiome modulation strategies for health benefits.

AB - The human intestinal tract harbors one of the most densely populated and open microbial ecosystems. The application of multi-omics approaches has provided insight into a wide array of complex interactions between the various groups of mainly anaerobic colonic microbes as well as the host–microbe dialogue. Integration of multi-omics techniques in cultivation based experiments that vary in complexity from monocultures to synthetic microbial communities identified key metabolic players in the trophic interactions as well as their ecological dynamics. A synergy between these approaches will be of utmost importance to reconstruct the functional interaction networks at the ecosystem level within the human intestinal microbiome. The improved understanding of microbiome functioning at ecosystem level will further aid in developing better predictive models and design of effective microbiome modulation strategies for health benefits.

KW - 3111 Biomedicine

U2 - 10.1016/j.copbio.2019.03.009

DO - 10.1016/j.copbio.2019.03.009

M3 - Article

VL - 58

SP - 146

EP - 154

JO - Current Opinion in Biotechnology

JF - Current Opinion in Biotechnology

SN - 0958-1669

ER -