Regulation of integrin activity and signalling

Carl G. Gahmberg, Susanna C. Fagerholm, Susanna M. Nurmi, Triantafyllos Chavakis, Silvia Marchesan, Mikaela Grönholm

    Forskningsoutput: TidskriftsbidragÖversiktsartikelVetenskapligPeer review

    Sammanfattning

    The ability of cells to attach to each other and to the extracellular matrix is of pivotal significance for the formation of functional organs and for the distribution of cells in the body. Several molecular families of proteins are involved in adhesion, and recent work has substantially improved Our understanding of their structures and functions. Also, these molecules are now being targeted in the fight against disease. However, less is known about how their activity is regulated. It is apparent that among the different classes of adhesion molecules, the integrin family of adhesion receptors is unique in the sense that they constitute a large group of widely distributed receptors, they are unusually complex and most importantly their activities are strictly regulated from the inside of the cell. The activity regulation is achieved by a complex interplay of cytoskeletal proteins, protein kinases, phosphatases, small G proteins and adaptor proteins. Obviously, we are only in the beginning of our understanding of how the integrins function, but already now fascinating details have become apparent. Here, we describe recent progress in the field, concentrating mainly on mechanistical and structural studies of integrin regulation. Due to the large number of articles dealing with integrins, we focus on what we think are the most exciting and rewarding directions of contemporary research on cell adhesion and integrins. (C) 2009 Elsevier B.V. All rights reserved.
    Originalspråkengelska
    TidskriftBiochimica et Biophysica Acta. General Subjects
    Volym1790
    Utgåva6
    Sidor (från-till)431-444
    Antal sidor14
    ISSN0304-4165
    DOI
    StatusPublicerad - 2009
    MoE-publikationstypA2 Granska artikel i en vetenskaplig tidskrift

    Vetenskapsgrenar

    • 311 Basmedicin
    • 318 Medicinsk bioteknologi
    • 118 Biovetenskaper

    Citera det här

    Gahmberg, Carl G. ; Fagerholm, Susanna C. ; Nurmi, Susanna M. ; Chavakis, Triantafyllos ; Marchesan, Silvia ; Grönholm, Mikaela. / Regulation of integrin activity and signalling. I: Biochimica et Biophysica Acta. General Subjects. 2009 ; Vol. 1790, Nr. 6. s. 431-444.
    @article{1ddc3f2589e74a41bf92a5913828cd7f,
    title = "Regulation of integrin activity and signalling",
    abstract = "The ability of cells to attach to each other and to the extracellular matrix is of pivotal significance for the formation of functional organs and for the distribution of cells in the body. Several molecular families of proteins are involved in adhesion, and recent work has substantially improved Our understanding of their structures and functions. Also, these molecules are now being targeted in the fight against disease. However, less is known about how their activity is regulated. It is apparent that among the different classes of adhesion molecules, the integrin family of adhesion receptors is unique in the sense that they constitute a large group of widely distributed receptors, they are unusually complex and most importantly their activities are strictly regulated from the inside of the cell. The activity regulation is achieved by a complex interplay of cytoskeletal proteins, protein kinases, phosphatases, small G proteins and adaptor proteins. Obviously, we are only in the beginning of our understanding of how the integrins function, but already now fascinating details have become apparent. Here, we describe recent progress in the field, concentrating mainly on mechanistical and structural studies of integrin regulation. Due to the large number of articles dealing with integrins, we focus on what we think are the most exciting and rewarding directions of contemporary research on cell adhesion and integrins. (C) 2009 Elsevier B.V. All rights reserved.",
    keywords = "Leukocyte, Signalling, Integrin, LFA-1, Phosphorylation, PROTEIN-KINASE-C, INTERCELLULAR-ADHESION MOLECULE, EXTRACELLULAR ADHERENCE PROTEIN, CD11/CD18 LEUKOCYTE INTEGRINS, INFLAMMATORY CELL RECRUITMENT, T-CELL, STRUCTURAL BASIS, CYTOPLASMIC DOMAIN, BETA-SUBUNIT, CRYSTAL-STRUCTURE, 311 Basic medicine, 318 Medical biotechnology, 118 Biological sciences",
    author = "Gahmberg, {Carl G.} and Fagerholm, {Susanna C.} and Nurmi, {Susanna M.} and Triantafyllos Chavakis and Silvia Marchesan and Mikaela Gr{\"o}nholm",
    year = "2009",
    doi = "10.1016/j.bbagen.2009.03.007",
    language = "English",
    volume = "1790",
    pages = "431--444",
    journal = "Biochimica et Biophysica Acta. General Subjects",
    issn = "0304-4165",
    publisher = "Elsevier Scientific Publ. Co",
    number = "6",

    }

    Regulation of integrin activity and signalling. / Gahmberg, Carl G.; Fagerholm, Susanna C.; Nurmi, Susanna M.; Chavakis, Triantafyllos; Marchesan, Silvia; Grönholm, Mikaela.

    I: Biochimica et Biophysica Acta. General Subjects, Vol. 1790, Nr. 6, 2009, s. 431-444.

    Forskningsoutput: TidskriftsbidragÖversiktsartikelVetenskapligPeer review

    TY - JOUR

    T1 - Regulation of integrin activity and signalling

    AU - Gahmberg, Carl G.

    AU - Fagerholm, Susanna C.

    AU - Nurmi, Susanna M.

    AU - Chavakis, Triantafyllos

    AU - Marchesan, Silvia

    AU - Grönholm, Mikaela

    PY - 2009

    Y1 - 2009

    N2 - The ability of cells to attach to each other and to the extracellular matrix is of pivotal significance for the formation of functional organs and for the distribution of cells in the body. Several molecular families of proteins are involved in adhesion, and recent work has substantially improved Our understanding of their structures and functions. Also, these molecules are now being targeted in the fight against disease. However, less is known about how their activity is regulated. It is apparent that among the different classes of adhesion molecules, the integrin family of adhesion receptors is unique in the sense that they constitute a large group of widely distributed receptors, they are unusually complex and most importantly their activities are strictly regulated from the inside of the cell. The activity regulation is achieved by a complex interplay of cytoskeletal proteins, protein kinases, phosphatases, small G proteins and adaptor proteins. Obviously, we are only in the beginning of our understanding of how the integrins function, but already now fascinating details have become apparent. Here, we describe recent progress in the field, concentrating mainly on mechanistical and structural studies of integrin regulation. Due to the large number of articles dealing with integrins, we focus on what we think are the most exciting and rewarding directions of contemporary research on cell adhesion and integrins. (C) 2009 Elsevier B.V. All rights reserved.

    AB - The ability of cells to attach to each other and to the extracellular matrix is of pivotal significance for the formation of functional organs and for the distribution of cells in the body. Several molecular families of proteins are involved in adhesion, and recent work has substantially improved Our understanding of their structures and functions. Also, these molecules are now being targeted in the fight against disease. However, less is known about how their activity is regulated. It is apparent that among the different classes of adhesion molecules, the integrin family of adhesion receptors is unique in the sense that they constitute a large group of widely distributed receptors, they are unusually complex and most importantly their activities are strictly regulated from the inside of the cell. The activity regulation is achieved by a complex interplay of cytoskeletal proteins, protein kinases, phosphatases, small G proteins and adaptor proteins. Obviously, we are only in the beginning of our understanding of how the integrins function, but already now fascinating details have become apparent. Here, we describe recent progress in the field, concentrating mainly on mechanistical and structural studies of integrin regulation. Due to the large number of articles dealing with integrins, we focus on what we think are the most exciting and rewarding directions of contemporary research on cell adhesion and integrins. (C) 2009 Elsevier B.V. All rights reserved.

    KW - Leukocyte

    KW - Signalling

    KW - Integrin

    KW - LFA-1

    KW - Phosphorylation

    KW - PROTEIN-KINASE-C

    KW - INTERCELLULAR-ADHESION MOLECULE

    KW - EXTRACELLULAR ADHERENCE PROTEIN

    KW - CD11/CD18 LEUKOCYTE INTEGRINS

    KW - INFLAMMATORY CELL RECRUITMENT

    KW - T-CELL

    KW - STRUCTURAL BASIS

    KW - CYTOPLASMIC DOMAIN

    KW - BETA-SUBUNIT

    KW - CRYSTAL-STRUCTURE

    KW - 311 Basic medicine

    KW - 318 Medical biotechnology

    KW - 118 Biological sciences

    U2 - 10.1016/j.bbagen.2009.03.007

    DO - 10.1016/j.bbagen.2009.03.007

    M3 - Review Article

    VL - 1790

    SP - 431

    EP - 444

    JO - Biochimica et Biophysica Acta. General Subjects

    JF - Biochimica et Biophysica Acta. General Subjects

    SN - 0304-4165

    IS - 6

    ER -