Regulation of nuclear actin dynamics in development and disease

Forskningsoutput: TidskriftsbidragÖversiktsartikelPeer review

Sammanfattning

Actin has essential functions both in the cytoplasm and in the nucleus, where it has been linked to key nuclear processes, from transcription to DNA damage response. The multifunctional nature of actin suggests that the cell must contain mechanisms to accurately control the cellular actin balance. Indeed, recent results have demonstrated that nuclear actin levels fluctuate to regulate the transcriptional activity of the cell and that controlled nuclear actin polymerization is required for transcription activation, cell cycle progression, and DNA repair. Intriguingly, aberrant nuclear actin regulation has been observed, for example, in cancer, signifying the importance of this process for cellular homeostasis. This review discussed the latest research on how nuclear actin is regulated, and how this influences actin-dependent nuclear processes.
Originalspråkengelska
TidskriftCurrent Opinion in Cell Biology
Volym64
Sidor (från-till)18-24
Antal sidor7
ISSN0955-0674
DOI
StatusPublicerad - juni 2020
MoE-publikationstypA2 Granska artikel i en vetenskaplig tidskrift

Vetenskapsgrenar

  • 1182 Biokemi, cell- och molekylärbiologi

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