Role of the microRNA-29 family in fibrotic skin diseases

Duygu Harmanci, Erdogan Pekcan Erkan, Ayse Kocak, Gul Akdogan

Forskningsoutput: TidskriftsbidragÖversiktsartikelVetenskapligPeer review

Sammanfattning

Fibrotic skin diseases are characterized by the accumulation of collagen. The hallmarks of fibrotic skin diseases are unbalanced fibroblast proliferation and differentiation, extracellular matrix production and transforming growth factor‑β signalling. Numerous studies have investigated the possibility that microRNAs (miRNAs or miRs) are involved in the pathogenesis of certain fibrotic diseases, including skin, heart, lung and liver diseases. miRNAs are a class of small non‑coding RNAs, which modify gene expression by binding to target messenger RNA (mRNA) and blocking the translation or inducing the degradation of target mRNA. The biological relevance of miRNAs has been investigated in physiological and pathological conditions, and there is increasing evidence that the miR‑29 family is associated with fibrotic diseases. The aim of the present review is to provide an up‑to‑date summary of current knowledge on the latest developments associated with the miR‑29 family and fibrotic skin diseases.
Originalspråkengelska
TidskriftBiomedical Reports
Volym6
Utgåva6
Sidor (från-till)599-604
ISSN2049-9434
DOI
StatusPublicerad - jun 2017
MoE-publikationstypA2 Granska artikel i en vetenskaplig tidskrift

Vetenskapsgrenar

  • 3111 Biomedicinska vetenskaper

Citera det här

Harmanci, Duygu ; Erkan, Erdogan Pekcan ; Kocak, Ayse ; Akdogan, Gul. / Role of the microRNA-29 family in fibrotic skin diseases. I: Biomedical Reports. 2017 ; Vol. 6, Nr. 6. s. 599-604.
@article{097bf2fee0ba4092a50c2f0c18efeaac,
title = "Role of the microRNA-29 family in fibrotic skin diseases",
abstract = "Fibrotic skin diseases are characterized by the accumulation of collagen. The hallmarks of fibrotic skin diseases are unbalanced fibroblast proliferation and differentiation, extracellular matrix production and transforming growth factor‑β signalling. Numerous studies have investigated the possibility that microRNAs (miRNAs or miRs) are involved in the pathogenesis of certain fibrotic diseases, including skin, heart, lung and liver diseases. miRNAs are a class of small non‑coding RNAs, which modify gene expression by binding to target messenger RNA (mRNA) and blocking the translation or inducing the degradation of target mRNA. The biological relevance of miRNAs has been investigated in physiological and pathological conditions, and there is increasing evidence that the miR‑29 family is associated with fibrotic diseases. The aim of the present review is to provide an up‑to‑date summary of current knowledge on the latest developments associated with the miR‑29 family and fibrotic skin diseases.",
keywords = "3111 Biomedicine",
author = "Duygu Harmanci and Erkan, {Erdogan Pekcan} and Ayse Kocak and Gul Akdogan",
year = "2017",
month = "6",
doi = "10.3892/br.2017.900",
language = "English",
volume = "6",
pages = "599--604",
journal = "Biomedical Reports",
issn = "2049-9434",
publisher = "Spandidos Publications",
number = "6",

}

Role of the microRNA-29 family in fibrotic skin diseases. / Harmanci, Duygu; Erkan, Erdogan Pekcan; Kocak, Ayse; Akdogan, Gul.

I: Biomedical Reports, Vol. 6, Nr. 6, 06.2017, s. 599-604.

Forskningsoutput: TidskriftsbidragÖversiktsartikelVetenskapligPeer review

TY - JOUR

T1 - Role of the microRNA-29 family in fibrotic skin diseases

AU - Harmanci, Duygu

AU - Erkan, Erdogan Pekcan

AU - Kocak, Ayse

AU - Akdogan, Gul

PY - 2017/6

Y1 - 2017/6

N2 - Fibrotic skin diseases are characterized by the accumulation of collagen. The hallmarks of fibrotic skin diseases are unbalanced fibroblast proliferation and differentiation, extracellular matrix production and transforming growth factor‑β signalling. Numerous studies have investigated the possibility that microRNAs (miRNAs or miRs) are involved in the pathogenesis of certain fibrotic diseases, including skin, heart, lung and liver diseases. miRNAs are a class of small non‑coding RNAs, which modify gene expression by binding to target messenger RNA (mRNA) and blocking the translation or inducing the degradation of target mRNA. The biological relevance of miRNAs has been investigated in physiological and pathological conditions, and there is increasing evidence that the miR‑29 family is associated with fibrotic diseases. The aim of the present review is to provide an up‑to‑date summary of current knowledge on the latest developments associated with the miR‑29 family and fibrotic skin diseases.

AB - Fibrotic skin diseases are characterized by the accumulation of collagen. The hallmarks of fibrotic skin diseases are unbalanced fibroblast proliferation and differentiation, extracellular matrix production and transforming growth factor‑β signalling. Numerous studies have investigated the possibility that microRNAs (miRNAs or miRs) are involved in the pathogenesis of certain fibrotic diseases, including skin, heart, lung and liver diseases. miRNAs are a class of small non‑coding RNAs, which modify gene expression by binding to target messenger RNA (mRNA) and blocking the translation or inducing the degradation of target mRNA. The biological relevance of miRNAs has been investigated in physiological and pathological conditions, and there is increasing evidence that the miR‑29 family is associated with fibrotic diseases. The aim of the present review is to provide an up‑to‑date summary of current knowledge on the latest developments associated with the miR‑29 family and fibrotic skin diseases.

KW - 3111 Biomedicine

U2 - 10.3892/br.2017.900

DO - 10.3892/br.2017.900

M3 - Review Article

VL - 6

SP - 599

EP - 604

JO - Biomedical Reports

JF - Biomedical Reports

SN - 2049-9434

IS - 6

ER -