Short-interval intracortical inhibition in human primary motor cortex: A multi-locus transcranial magnetic stimulation study

Jaakko O. Nieminen, Lari M. Koponen, Niko Mäkelä, Victor Hugo Souza, Matti Stenroos, Risto J. Ilmoniemi

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Sammanfattning

Short-interval intracortical inhibition (SICI) has been studied with paired-pulse transcranial magnetic stimulation (TMS) by administering two pulses at a millisecond-scale interstimulus interval (ISI) to a single cortical target. It has, however, been difficult to study the interaction of nearby cortical targets with paired-pulse TMS. To overcome this limitation, we have developed a multi-locus TMS (mTMS) device, which allows controlling the stimulus location electronically. Here, we applied mTMS to study SICI in primary motor cortex with paired pulses targeted to adjacent locations, aiming to quantify the extent of the cortical region producing SICI in the location of a test stimulus. We varied the location and timing of the conditioning stimulus with respect to a test stimulus targeted to the cortical hotspot of the abductor pollicis brevis (APB) in order to study their effects on motor evoked potentials. We further applied a two-coil protocol with the conditioning stimulus given by an oval coil only to the surroundings of the APB hotspot, to which a subsequent test stimulus was administered with a figure-of-eight coil. The strongest SICI occurred at ISIs below 1 ms and at ISIs around 2.5 ms. These ISIs increased when the conditioning stimulus receded from the APB hotspot. Our two-coil paired-pulse TMS study suggests that SICI at ISIs of 0.5 and 2.5 ms originate from different mechanisms or neuronal elements.
Originalspråkengelska
TidskriftNeuroImage
ISSN1053-8119
DOI
StatusPublicerad - 13 sep 2019
MoE-publikationstypA1 Tidskriftsartikel-refererad

Vetenskapsgrenar

  • 3112 Neurovetenskaper

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title = "Short-interval intracortical inhibition in human primary motor cortex: A multi-locus transcranial magnetic stimulation study",
abstract = "Short-interval intracortical inhibition (SICI) has been studied with paired-pulse transcranial magnetic stimulation (TMS) by administering two pulses at a millisecond-scale interstimulus interval (ISI) to a single cortical target. It has, however, been difficult to study the interaction of nearby cortical targets with paired-pulse TMS. To overcome this limitation, we have developed a multi-locus TMS (mTMS) device, which allows controlling the stimulus location electronically. Here, we applied mTMS to study SICI in primary motor cortex with paired pulses targeted to adjacent locations, aiming to quantify the extent of the cortical region producing SICI in the location of a test stimulus. We varied the location and timing of the conditioning stimulus with respect to a test stimulus targeted to the cortical hotspot of the abductor pollicis brevis (APB) in order to study their effects on motor evoked potentials. We further applied a two-coil protocol with the conditioning stimulus given by an oval coil only to the surroundings of the APB hotspot, to which a subsequent test stimulus was administered with a figure-of-eight coil. The strongest SICI occurred at ISIs below 1 ms and at ISIs around 2.5 ms. These ISIs increased when the conditioning stimulus receded from the APB hotspot. Our two-coil paired-pulse TMS study suggests that SICI at ISIs of 0.5 and 2.5 ms originate from different mechanisms or neuronal elements.",
keywords = "Multi-locus transcranial magnetic stimulation, Short-interval intracortical inhibition, Motor cortex, Motor evoked potential, Transcranial magnetic stimulation, Transducer, 3112 Neurosciences",
author = "Nieminen, {Jaakko O.} and Koponen, {Lari M.} and Niko M{\"a}kel{\"a} and Souza, {Victor Hugo} and Matti Stenroos and Ilmoniemi, {Risto J.}",
year = "2019",
month = "9",
day = "13",
doi = "10.1016/j.neuroimage.2019.116194",
language = "English",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "ACADEMIC PRESS INC ELSEVIER SCIENCE",

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Short-interval intracortical inhibition in human primary motor cortex: A multi-locus transcranial magnetic stimulation study. / Nieminen, Jaakko O.; Koponen, Lari M.; Mäkelä, Niko; Souza, Victor Hugo; Stenroos, Matti; Ilmoniemi, Risto J.

I: NeuroImage, 13.09.2019.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

TY - JOUR

T1 - Short-interval intracortical inhibition in human primary motor cortex: A multi-locus transcranial magnetic stimulation study

AU - Nieminen, Jaakko O.

AU - Koponen, Lari M.

AU - Mäkelä, Niko

AU - Souza, Victor Hugo

AU - Stenroos, Matti

AU - Ilmoniemi, Risto J.

PY - 2019/9/13

Y1 - 2019/9/13

N2 - Short-interval intracortical inhibition (SICI) has been studied with paired-pulse transcranial magnetic stimulation (TMS) by administering two pulses at a millisecond-scale interstimulus interval (ISI) to a single cortical target. It has, however, been difficult to study the interaction of nearby cortical targets with paired-pulse TMS. To overcome this limitation, we have developed a multi-locus TMS (mTMS) device, which allows controlling the stimulus location electronically. Here, we applied mTMS to study SICI in primary motor cortex with paired pulses targeted to adjacent locations, aiming to quantify the extent of the cortical region producing SICI in the location of a test stimulus. We varied the location and timing of the conditioning stimulus with respect to a test stimulus targeted to the cortical hotspot of the abductor pollicis brevis (APB) in order to study their effects on motor evoked potentials. We further applied a two-coil protocol with the conditioning stimulus given by an oval coil only to the surroundings of the APB hotspot, to which a subsequent test stimulus was administered with a figure-of-eight coil. The strongest SICI occurred at ISIs below 1 ms and at ISIs around 2.5 ms. These ISIs increased when the conditioning stimulus receded from the APB hotspot. Our two-coil paired-pulse TMS study suggests that SICI at ISIs of 0.5 and 2.5 ms originate from different mechanisms or neuronal elements.

AB - Short-interval intracortical inhibition (SICI) has been studied with paired-pulse transcranial magnetic stimulation (TMS) by administering two pulses at a millisecond-scale interstimulus interval (ISI) to a single cortical target. It has, however, been difficult to study the interaction of nearby cortical targets with paired-pulse TMS. To overcome this limitation, we have developed a multi-locus TMS (mTMS) device, which allows controlling the stimulus location electronically. Here, we applied mTMS to study SICI in primary motor cortex with paired pulses targeted to adjacent locations, aiming to quantify the extent of the cortical region producing SICI in the location of a test stimulus. We varied the location and timing of the conditioning stimulus with respect to a test stimulus targeted to the cortical hotspot of the abductor pollicis brevis (APB) in order to study their effects on motor evoked potentials. We further applied a two-coil protocol with the conditioning stimulus given by an oval coil only to the surroundings of the APB hotspot, to which a subsequent test stimulus was administered with a figure-of-eight coil. The strongest SICI occurred at ISIs below 1 ms and at ISIs around 2.5 ms. These ISIs increased when the conditioning stimulus receded from the APB hotspot. Our two-coil paired-pulse TMS study suggests that SICI at ISIs of 0.5 and 2.5 ms originate from different mechanisms or neuronal elements.

KW - Multi-locus transcranial magnetic stimulation

KW - Short-interval intracortical inhibition

KW - Motor cortex

KW - Motor evoked potential

KW - Transcranial magnetic stimulation

KW - Transducer

KW - 3112 Neurosciences

U2 - 10.1016/j.neuroimage.2019.116194

DO - 10.1016/j.neuroimage.2019.116194

M3 - Article

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

ER -