Spatial aspects of oncogenic signalling determine the response to combination therapy in slice explants from Kras-driven lung tumours

Katja Närhi, Ashwini S. Nagaraj, Elina Parri, Riku Turkki, Petra W. van Duijn, Annabrita Hemmes, Jenni Lahtela, Virva Uotinen, Mikko I. Mäyränpää, Kaisa Salmenkivi, Jari Räsänen, Nina Linder, Jan Trapman, Antti Rannikko, Olli Kallioniemi, Taija M. Af Hällström, Johan Lundin, Wolfgang Sommergruber, Simon Anders, Emmy W. Verschuren

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Originalspråkengelska
TidskriftJournal of Pathology
Volym245
Utgåva1
Sidor (från-till)101-113
Antal sidor13
ISSN0022-3417
DOI
StatusPublicerad - maj 2018
MoE-publikationstypA1 Tidskriftsartikel-refererad

Vetenskapsgrenar

  • 3126 Kirurgi, anestesiologi, intensivvård, radiologi
  • 3122 Cancersjukdomar
  • 3111 Biomedicinska vetenskaper

Citera det här

@article{1b1d18e49bff4d2ab9d64bacb8f36b1f,
title = "Spatial aspects of oncogenic signalling determine the response to combination therapy in slice explants from Kras-driven lung tumours",
keywords = "non-small-cell lung cancer, prostate cancer, oncogenic signalling, precision-cut slices, targeted therapy, spatial heterogeneity, SQUAMOUS-CELL CARCINOMA, MUTANT KRAS, MOUSE LUNG, CANCER, ADENOCARCINOMA, LKB1, RAS, INACTIVATION, ORIGIN, CULTURES, 3126 Surgery, anesthesiology, intensive care, radiology, 3122 Cancers, 3111 Biomedicine",
author = "Katja N{\"a}rhi and Nagaraj, {Ashwini S.} and Elina Parri and Riku Turkki and {van Duijn}, {Petra W.} and Annabrita Hemmes and Jenni Lahtela and Virva Uotinen and M{\"a}yr{\"a}np{\"a}{\"a}, {Mikko I.} and Kaisa Salmenkivi and Jari R{\"a}s{\"a}nen and Nina Linder and Jan Trapman and Antti Rannikko and Olli Kallioniemi and {Af H{\"a}llstr{\"o}m}, {Taija M.} and Johan Lundin and Wolfgang Sommergruber and Simon Anders and Verschuren, {Emmy W.}",
year = "2018",
month = "5",
doi = "10.1002/path.5059",
language = "English",
volume = "245",
pages = "101--113",
journal = "Journal of Pathology",
issn = "0022-3417",
publisher = "John Wiley & Sons Ltd.",
number = "1",

}

TY - JOUR

T1 - Spatial aspects of oncogenic signalling determine the response to combination therapy in slice explants from Kras-driven lung tumours

AU - Närhi, Katja

AU - Nagaraj, Ashwini S.

AU - Parri, Elina

AU - Turkki, Riku

AU - van Duijn, Petra W.

AU - Hemmes, Annabrita

AU - Lahtela, Jenni

AU - Uotinen, Virva

AU - Mäyränpää, Mikko I.

AU - Salmenkivi, Kaisa

AU - Räsänen, Jari

AU - Linder, Nina

AU - Trapman, Jan

AU - Rannikko, Antti

AU - Kallioniemi, Olli

AU - Af Hällström, Taija M.

AU - Lundin, Johan

AU - Sommergruber, Wolfgang

AU - Anders, Simon

AU - Verschuren, Emmy W.

PY - 2018/5

Y1 - 2018/5

KW - non-small-cell lung cancer

KW - prostate cancer

KW - oncogenic signalling

KW - precision-cut slices

KW - targeted therapy

KW - spatial heterogeneity

KW - SQUAMOUS-CELL CARCINOMA

KW - MUTANT KRAS

KW - MOUSE LUNG

KW - CANCER

KW - ADENOCARCINOMA

KW - LKB1

KW - RAS

KW - INACTIVATION

KW - ORIGIN

KW - CULTURES

KW - 3126 Surgery, anesthesiology, intensive care, radiology

KW - 3122 Cancers

KW - 3111 Biomedicine

U2 - 10.1002/path.5059

DO - 10.1002/path.5059

M3 - Article

VL - 245

SP - 101

EP - 113

JO - Journal of Pathology

JF - Journal of Pathology

SN - 0022-3417

IS - 1

ER -