STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer

Liya Ding; Qiwei Wang; Antons Martincuks; Michael J. Kearns; Tao Jiang; Ziying Lin; Xin Cheng; Changli Qian; Shaozhen Xie; Hye-Jung Kim; Inga-Maria Launonen; Anniina Färkkilä; Thomas M. Roberts; Gordon J. Freeman; Joyce F. Liu; Panagiotis A. Konstantinopoulos; Ursula Matulonis; Hua Yu; Jean J. Zhao

doi:10.1136/jitc-2022-005627

STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer

Liya Ding, Qiwei Wang, Antons Martincuks, Michael J. Kearns, Tao Jiang, Ziying Lin, Xin Cheng, Changli Qian, Shaozhen Xie, Hye-Jung Kim, Inga-Maria Launonen, Anniina Färkkilä, Thomas M. Roberts, Gordon J. Freeman, Joyce F. Liu, Panagiotis A. Konstantinopoulos, Ursula Matulonis, Hua Yu, Jean J. Zhao

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

Originalspråk	engelska
Artikelnummer	e005627
Tidskrift	Journal for Immunotherapy of Cancer
Volym	11
Nummer	1
Antal sidor	15
ISSN	2051-1426
DOI	https://doi.org/10.1136/jitc-2022-005627
Status	Publicerad - jan. 2023
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

Vetenskapsgrenar

3122 Cancersjukdomar

Åtkomst av dokument

10.1136/jitc-2022-005627

e005627.fullSlutlig publicerad version, 6,48 MBLicens: CC BY-NC

Discovery and therapeutic exploitation of immunological vulnerabilities in ovarian cancer
Färkkilä, A. (Projektledare), Kang, Z. (Deltagare), Niemiec, I. (Deltagare), Nagaraj, A. (Deltagare), Perez Villatoro, F. R. (Deltagare), Chernenko, A. (Deltagare) & Shah, S. (Deltagare)
01/01/2021 → 31/12/2023
Projekt: Helsingfors Universitetets treåriga forskningsprojekt

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Ding, L., Wang, Q., Martincuks, A., Kearns, M. J., Jiang, T., Lin, Z., Cheng, X., Qian, C., Xie, S., Kim, H.-J., Launonen, I.-M., Färkkilä, A., Roberts, T. M., Freeman, G. J., Liu, J. F., Konstantinopoulos, P. A., Matulonis, U., Yu, H., & Zhao, J. J. (2023). STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer. Journal for Immunotherapy of Cancer, 11(1), Artikel e005627. https://doi.org/10.1136/jitc-2022-005627

@article{5a9204d9cd8e4c8ab2a16dba95bb4b69,

title = "STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer",

keywords = "Combination, Drug Therapy, Immunomodulation, Immunotherapy, Macrophages, Tumor Microenvironment, 3122 Cancers",

author = "Liya Ding and Qiwei Wang and Antons Martincuks and Kearns, {Michael J.} and Tao Jiang and Ziying Lin and Xin Cheng and Changli Qian and Shaozhen Xie and Hye-Jung Kim and Inga-Maria Launonen and Anniina F{\"a}rkkil{\"a} and Roberts, {Thomas M.} and Freeman, {Gordon J.} and Liu, {Joyce F.} and Konstantinopoulos, {Panagiotis A.} and Ursula Matulonis and Hua Yu and Zhao, {Jean J.}",

year = "2023",

month = jan,

doi = "10.1136/jitc-2022-005627",

language = "English",

volume = "11",

journal = "Journal for Immunotherapy of Cancer",

issn = "2051-1426",

publisher = "BMJ PUBLISHING GROUP",

number = "1",

}

Ding, L, Wang, Q, Martincuks, A, Kearns, MJ, Jiang, T, Lin, Z, Cheng, X, Qian, C, Xie, S, Kim, H-J, Launonen, I-M , Färkkilä, A, Roberts, TM, Freeman, GJ, Liu, JF, Konstantinopoulos, PA, Matulonis, U, Yu, H & Zhao, JJ 2023, 'STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer', Journal for Immunotherapy of Cancer, vol. 11, nr. 1, e005627. https://doi.org/10.1136/jitc-2022-005627

TY - JOUR

T1 - STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer

AU - Ding, Liya

AU - Wang, Qiwei

AU - Martincuks, Antons

AU - Kearns, Michael J.

AU - Jiang, Tao

AU - Lin, Ziying

AU - Cheng, Xin

AU - Qian, Changli

AU - Xie, Shaozhen

AU - Kim, Hye-Jung

AU - Launonen, Inga-Maria

AU - Färkkilä, Anniina

AU - Roberts, Thomas M.

AU - Freeman, Gordon J.

AU - Liu, Joyce F.

AU - Konstantinopoulos, Panagiotis A.

AU - Matulonis, Ursula

AU - Yu, Hua

AU - Zhao, Jean J.

PY - 2023/1

Y1 - 2023/1

KW - Combination

KW - Drug Therapy

KW - Immunomodulation

KW - Immunotherapy

KW - Macrophages

KW - Tumor Microenvironment

KW - 3122 Cancers

U2 - 10.1136/jitc-2022-005627

DO - 10.1136/jitc-2022-005627

M3 - Article

C2 - 36609487

SN - 2051-1426

VL - 11

JO - Journal for Immunotherapy of Cancer

JF - Journal for Immunotherapy of Cancer

IS - 1

M1 - e005627

ER -

STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer

Vetenskapsgrenar

Åtkomst av dokument

Projekt

Discovery and therapeutic exploitation of immunological vulnerabilities in ovarian cancer

Citera det här