Surgeon experience in glioblastoma surgery of the elderly: a multicenter, retrospective cohort study

Johannes P. Pöppe; Lukas Machegger; Juergen Steinbacher; Harald Stefanits; Sophie Eisschiel; Andreas Gruber; Matthias Demetz; Barbara Ladisich; Theo F. J. Kraus; Serge Weis; Sabine Spiegl-Kreinecker; Alexander Romagna; Christoph J. Griessenauer; Behnam Rezai Jahromi; Ilari Rautalin; Mika Niemelä; Miikka Korja; Christoph Schwartz

doi:10.1007/s11060-023-04252-3

Surgeon experience in glioblastoma surgery of the elderly: a multicenter, retrospective cohort study

Johannes P. Pöppe, Lukas Machegger, Juergen Steinbacher, Harald Stefanits, Sophie Eisschiel, Andreas Gruber, Matthias Demetz, Barbara Ladisich, Theo F. J. Kraus, Serge Weis, Sabine Spiegl-Kreinecker, Alexander Romagna, Christoph J. Griessenauer, Behnam Rezai Jahromi, Ilari Rautalin, Mika Niemelä, Miikka Korja, Christoph Schwartz

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

Sammanfattning

Purpose To assess the impact of individual surgeon experience on overall survival (OS), extent of resection (EOR) and surgery-related morbidity in elderly patients with glioblastoma (GBM), we performed a retrospective case-by-case analysis.
Methods GBM patients aged≥65 years who underwent tumor resection at two academic centers were analyzed. The experience of each neurosurgeon was quantifed in three ways: (1) total number of previously performed glioma surgeries (lifetime experience); (2) number of surgeries performed in the previous fve years (medium-term experience) and (3) in the last two years (short-term experience). Surgeon experience data was correlated with survival (OS) and surrogate parameters for surgical quality (EOR, morbidity).
Results 198 GBM patients (median age 73.0 years, median preoperative KPS 80, IDH-wildtype status 96.5%) were included. Median OS was 10.0 months (95% CI 8.0–12.0); median EOR was 89.4%. Surgery-related morbidity afected 19.7% patients. No correlations of lifetime surgeon experience with OS (P=.693), EOR (P=.693), and surgery-related morbidity (P=.435) were identifed. Adjuvant therapy was associated with improved OS (PConclusion Less experienced neurosurgeons achieve similar surgical results and outcome in elderly GBM patients within the setting of academic teaching hospitals. Adjuvant treatment and avoidance of surgery-related morbidity are crucial forgenerating a treatment beneft for this cohort.

Originalspråk	engelska
Tidskrift	Journal of Neuro-Oncology
Volym	161
Nummer	3
Sidor (från-till)	563-572
Antal sidor	10
ISSN	0167-594X
DOI	https://doi.org/10.1007/s11060-023-04252-3
Status	Publicerad - feb. 2023
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

Vetenskapsgrenar

3124 Neurologi och psykiatri

Åtkomst av dokument

10.1007/s11060-023-04252-3Licens: CC BY

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Citera det här

Pöppe, J. P., Machegger, L., Steinbacher, J., Stefanits, H., Eisschiel, S., Gruber, A., Demetz, M., Ladisich, B., Kraus, T. F. J., Weis, S., Spiegl-Kreinecker, S., Romagna, A., Griessenauer, C. J., Jahromi, B. R., Rautalin, I., Niemelä, M., Korja, M., & Schwartz, C. (2023). Surgeon experience in glioblastoma surgery of the elderly: a multicenter, retrospective cohort study. Journal of Neuro-Oncology, 161(3), 563-572. https://doi.org/10.1007/s11060-023-04252-3

@article{2037e3b344f844aeaa0be84e1eefb42f,

title = "Surgeon experience in glioblastoma surgery of the elderly: a multicenter, retrospective cohort study",

abstract = "Purpose To assess the impact of individual surgeon experience on overall survival (OS), extent of resection (EOR) and surgery-related morbidity in elderly patients with glioblastoma (GBM), we performed a retrospective case-by-case analysis.Methods GBM patients aged≥65 years who underwent tumor resection at two academic centers were analyzed. The experience of each neurosurgeon was quantifed in three ways: (1) total number of previously performed glioma surgeries (lifetime experience); (2) number of surgeries performed in the previous fve years (medium-term experience) and (3) in the last two years (short-term experience). Surgeon experience data was correlated with survival (OS) and surrogate parameters for surgical quality (EOR, morbidity).Results 198 GBM patients (median age 73.0 years, median preoperative KPS 80, IDH-wildtype status 96.5%) were included. Median OS was 10.0 months (95% CI 8.0–12.0); median EOR was 89.4%. Surgery-related morbidity afected 19.7% patients. No correlations of lifetime surgeon experience with OS (P=.693), EOR (P=.693), and surgery-related morbidity (P=.435) were identifed. Adjuvant therapy was associated with improved OS (PConclusion Less experienced neurosurgeons achieve similar surgical results and outcome in elderly GBM patients within the setting of academic teaching hospitals. Adjuvant treatment and avoidance of surgery-related morbidity are crucial forgenerating a treatment beneft for this cohort.",

keywords = "Elderly, Extent of resection, Glioblastoma, Morbidity, Outcome, Surgeon experience, 3124 Neurology and psychiatry",

author = "P{\"o}ppe, {Johannes P.} and Lukas Machegger and Juergen Steinbacher and Harald Stefanits and Sophie Eisschiel and Andreas Gruber and Matthias Demetz and Barbara Ladisich and Kraus, {Theo F. J.} and Serge Weis and Sabine Spiegl-Kreinecker and Alexander Romagna and Griessenauer, {Christoph J.} and Jahromi, {Behnam Rezai} and Ilari Rautalin and Mika Niemel{\"a} and Miikka Korja and Christoph Schwartz",

year = "2023",

month = feb,

doi = "10.1007/s11060-023-04252-3",

language = "English",

volume = "161",

pages = "563--572",

journal = "Journal of Neuro-Oncology",

issn = "0167-594X",

publisher = "Springer",

number = "3",

}

Pöppe, JP, Machegger, L, Steinbacher, J, Stefanits, H, Eisschiel, S, Gruber, A, Demetz, M, Ladisich, B, Kraus, TFJ, Weis, S, Spiegl-Kreinecker, S, Romagna, A, Griessenauer, CJ, Jahromi, BR, Rautalin, I, Niemelä, M , Korja, M & Schwartz, C 2023, 'Surgeon experience in glioblastoma surgery of the elderly: a multicenter, retrospective cohort study', Journal of Neuro-Oncology, vol. 161, nr. 3, s. 563-572. https://doi.org/10.1007/s11060-023-04252-3

TY - JOUR

T1 - Surgeon experience in glioblastoma surgery of the elderly

T2 - a multicenter, retrospective cohort study

AU - Pöppe, Johannes P.

AU - Machegger, Lukas

AU - Steinbacher, Juergen

AU - Stefanits, Harald

AU - Eisschiel, Sophie

AU - Gruber, Andreas

AU - Demetz, Matthias

AU - Ladisich, Barbara

AU - Kraus, Theo F. J.

AU - Weis, Serge

AU - Spiegl-Kreinecker, Sabine

AU - Romagna, Alexander

AU - Griessenauer, Christoph J.

AU - Jahromi, Behnam Rezai

AU - Rautalin, Ilari

AU - Niemelä, Mika

AU - Korja, Miikka

AU - Schwartz, Christoph

PY - 2023/2

Y1 - 2023/2

N2 - Purpose To assess the impact of individual surgeon experience on overall survival (OS), extent of resection (EOR) and surgery-related morbidity in elderly patients with glioblastoma (GBM), we performed a retrospective case-by-case analysis.Methods GBM patients aged≥65 years who underwent tumor resection at two academic centers were analyzed. The experience of each neurosurgeon was quantifed in three ways: (1) total number of previously performed glioma surgeries (lifetime experience); (2) number of surgeries performed in the previous fve years (medium-term experience) and (3) in the last two years (short-term experience). Surgeon experience data was correlated with survival (OS) and surrogate parameters for surgical quality (EOR, morbidity).Results 198 GBM patients (median age 73.0 years, median preoperative KPS 80, IDH-wildtype status 96.5%) were included. Median OS was 10.0 months (95% CI 8.0–12.0); median EOR was 89.4%. Surgery-related morbidity afected 19.7% patients. No correlations of lifetime surgeon experience with OS (P=.693), EOR (P=.693), and surgery-related morbidity (P=.435) were identifed. Adjuvant therapy was associated with improved OS (PConclusion Less experienced neurosurgeons achieve similar surgical results and outcome in elderly GBM patients within the setting of academic teaching hospitals. Adjuvant treatment and avoidance of surgery-related morbidity are crucial forgenerating a treatment beneft for this cohort.

AB - Purpose To assess the impact of individual surgeon experience on overall survival (OS), extent of resection (EOR) and surgery-related morbidity in elderly patients with glioblastoma (GBM), we performed a retrospective case-by-case analysis.Methods GBM patients aged≥65 years who underwent tumor resection at two academic centers were analyzed. The experience of each neurosurgeon was quantifed in three ways: (1) total number of previously performed glioma surgeries (lifetime experience); (2) number of surgeries performed in the previous fve years (medium-term experience) and (3) in the last two years (short-term experience). Surgeon experience data was correlated with survival (OS) and surrogate parameters for surgical quality (EOR, morbidity).Results 198 GBM patients (median age 73.0 years, median preoperative KPS 80, IDH-wildtype status 96.5%) were included. Median OS was 10.0 months (95% CI 8.0–12.0); median EOR was 89.4%. Surgery-related morbidity afected 19.7% patients. No correlations of lifetime surgeon experience with OS (P=.693), EOR (P=.693), and surgery-related morbidity (P=.435) were identifed. Adjuvant therapy was associated with improved OS (PConclusion Less experienced neurosurgeons achieve similar surgical results and outcome in elderly GBM patients within the setting of academic teaching hospitals. Adjuvant treatment and avoidance of surgery-related morbidity are crucial forgenerating a treatment beneft for this cohort.

KW - Elderly

KW - Extent of resection

KW - Glioblastoma

KW - Morbidity

KW - Outcome

KW - Surgeon experience

KW - 3124 Neurology and psychiatry

U2 - 10.1007/s11060-023-04252-3

DO - 10.1007/s11060-023-04252-3

M3 - Article

C2 - 36719614

SN - 0167-594X

VL - 161

SP - 563

EP - 572

JO - Journal of Neuro-Oncology

JF - Journal of Neuro-Oncology

IS - 3

ER -