Survival of nisin activity in intestinal environment

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Sammanfattning

The sensitivity of nisin to proteolytical breakdown in intestinal environment was studied in an ex vivo model using jejunal chyme from fistulated dogs. Sixty six percentage of the added nisin retained induction activity after 30 min incubation in jejunal chyme, indicating that nisin has potential to be used as an inducing agent in in situ delivery systems of bioactive peptides and proteins by genetically modified bacteria in the intestine.
Originalspråkengelska
TidskriftBiotechnology Letters
Volym31
Utgåva8
Sidor (från-till)1229-1232
Antal sidor4
ISSN0141-5492
DOI
StatusPublicerad - 2009
MoE-publikationstypA1 Tidskriftsartikel-refererad

Vetenskapsgrenar

  • 118 Biovetenskaper

Citera det här

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title = "Survival of nisin activity in intestinal environment",
abstract = "The sensitivity of nisin to proteolytical breakdown in intestinal environment was studied in an ex vivo model using jejunal chyme from fistulated dogs. Sixty six percentage of the added nisin retained induction activity after 30 min incubation in jejunal chyme, indicating that nisin has potential to be used as an inducing agent in in situ delivery systems of bioactive peptides and proteins by genetically modified bacteria in the intestine.",
keywords = "Chyme, Intestine, Nisin, Shelf life, LACTOCOCCUS-LACTIS, 118 Biological sciences",
author = "J. Reunanen and Saris, {P. E. J.}",
year = "2009",
doi = "10.1007/s10529-009-9995-3",
language = "English",
volume = "31",
pages = "1229--1232",
journal = "Biotechnology Letters",
issn = "0141-5492",
publisher = "SPRINGER NEW YORK LLC",
number = "8",

}

Survival of nisin activity in intestinal environment. / Reunanen, J.; Saris, P. E. J.

I: Biotechnology Letters, Vol. 31, Nr. 8, 2009, s. 1229-1232.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

TY - JOUR

T1 - Survival of nisin activity in intestinal environment

AU - Reunanen, J.

AU - Saris, P. E. J.

PY - 2009

Y1 - 2009

N2 - The sensitivity of nisin to proteolytical breakdown in intestinal environment was studied in an ex vivo model using jejunal chyme from fistulated dogs. Sixty six percentage of the added nisin retained induction activity after 30 min incubation in jejunal chyme, indicating that nisin has potential to be used as an inducing agent in in situ delivery systems of bioactive peptides and proteins by genetically modified bacteria in the intestine.

AB - The sensitivity of nisin to proteolytical breakdown in intestinal environment was studied in an ex vivo model using jejunal chyme from fistulated dogs. Sixty six percentage of the added nisin retained induction activity after 30 min incubation in jejunal chyme, indicating that nisin has potential to be used as an inducing agent in in situ delivery systems of bioactive peptides and proteins by genetically modified bacteria in the intestine.

KW - Chyme

KW - Intestine

KW - Nisin

KW - Shelf life

KW - LACTOCOCCUS-LACTIS

KW - 118 Biological sciences

U2 - 10.1007/s10529-009-9995-3

DO - 10.1007/s10529-009-9995-3

M3 - Article

VL - 31

SP - 1229

EP - 1232

JO - Biotechnology Letters

JF - Biotechnology Letters

SN - 0141-5492

IS - 8

ER -