Symptomatic psychosis risk and physiological fluctuation in functional MRI data

Aino Saarinen, Johannes Lieslehto, Vesa Kiviniemi, Jani Häkli, Timo Tuovinen, Mirka Hintsanen, Juha Veijola

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review


Background Physiological brain pulsations have been shown to play a critical role in maintaining interstitial homeostasis in the glymphatic brain clearance mechanism. We investigated whether psychotic symptomatology is related to the physiological variation of the human brain using fMRI. Methods The participants (N = 277) were from the Northern Finland Birth Cohort 1986. Psychotic symptoms were evaluated with the Positive Symptoms Scale of the Structured Interview for Prodromal Syndromes (SIPS). We used the coefficient of variation of BOLD signal (CVBOLD) as a proxy for physiological brain pulsatility. The CVBOLD-analyses were controlled for motion, age, sex, and educational level. The results were also compared with fMRI and voxel-based morphometry (VBM) meta-analyses of schizophrenia patients (data from the Brainmap database). Results At the global level, participants with psychotic-like symptoms had higher CVBOLD in cerebrospinal fluid (CSF) and white matter (WM), when compared to participants with no psychotic symptoms. Voxel-wise analyses revealed that CVBOLD was increased, especially in periventricular white matter, basal ganglia, cerebellum and parts of the cortical structures. Those brain regions, which included alterations of physiological fluctuation in symptomatic psychosis risk, overlapped
TidskriftSchizophrenia Research
Antal sidor8
Status!!E-pub ahead of print - 4 dec 2019
MoE-publikationstypA1 Tidskriftsartikel-refererad


  • 3112 Neurovetenskaper

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