Synthesis and biological evaluation of novel I-123-labeled 4-(4-iodophenyl)butanoyl-L-prolyl-(2S)-pyrrolidines for imaging prolyl oligopeptidase in vivo

Annukka Kallinen, Boyan Todorov, Roope Kallionpää, Susanne Back, Mirkka Sarparanta, Mad Raki, Juan A. Garcia-Horsman, Kim A. Bergstrom, Erik A. A. Wallen, Pekka T. Mannisto, Anu J. Airaksinen

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Originalspråkengelska
TidskriftEuropean Journal of Medicinal Chemistry
Volym79
Sidor (från-till)436-445
Antal sidor10
ISSN0223-5234
DOI
StatusPublicerad - 22 maj 2014
MoE-publikationstypA1 Tidskriftsartikel-refererad

Vetenskapsgrenar

  • 317 Farmaci
  • 116 Kemi

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@article{969d59f0835340f999b696965d2af94d,
title = "Synthesis and biological evaluation of novel I-123-labeled 4-(4-iodophenyl)butanoyl-L-prolyl-(2S)-pyrrolidines for imaging prolyl oligopeptidase in vivo",
keywords = "I-123-radiotracer, Prolyl oligopeptidase, Biodistribution, Inflammation, ALPHA-SYNUCLEIN, MULTIPLE-SCLEROSIS, PERIPHERAL-TISSUES, RAT STRIATUM, ENDOPEPTIDASE, INHIBITION, BRAIN, PARKINSONS, PEPTIDASES, KYP-2047, 317 Pharmacy, 116 Chemical sciences",
author = "Annukka Kallinen and Boyan Todorov and Roope Kallionp{\"a}{\"a} and Susanne Back and Mirkka Sarparanta and Mad Raki and Garcia-Horsman, {Juan A.} and Bergstrom, {Kim A.} and Wallen, {Erik A. A.} and Mannisto, {Pekka T.} and Airaksinen, {Anu J.}",
year = "2014",
month = "5",
day = "22",
doi = "10.1016/j.ejmech.2014.04.014",
language = "English",
volume = "79",
pages = "436--445",
journal = "European Journal of Medicinal Chemistry",
issn = "0223-5234",
publisher = "ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER",

}

Synthesis and biological evaluation of novel I-123-labeled 4-(4-iodophenyl)butanoyl-L-prolyl-(2S)-pyrrolidines for imaging prolyl oligopeptidase in vivo. / Kallinen, Annukka; Todorov, Boyan; Kallionpää, Roope; Back, Susanne; Sarparanta, Mirkka; Raki, Mad; Garcia-Horsman, Juan A.; Bergstrom, Kim A.; Wallen, Erik A. A.; Mannisto, Pekka T.; Airaksinen, Anu J.

I: European Journal of Medicinal Chemistry, Vol. 79, 22.05.2014, s. 436-445.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

TY - JOUR

T1 - Synthesis and biological evaluation of novel I-123-labeled 4-(4-iodophenyl)butanoyl-L-prolyl-(2S)-pyrrolidines for imaging prolyl oligopeptidase in vivo

AU - Kallinen, Annukka

AU - Todorov, Boyan

AU - Kallionpää, Roope

AU - Back, Susanne

AU - Sarparanta, Mirkka

AU - Raki, Mad

AU - Garcia-Horsman, Juan A.

AU - Bergstrom, Kim A.

AU - Wallen, Erik A. A.

AU - Mannisto, Pekka T.

AU - Airaksinen, Anu J.

PY - 2014/5/22

Y1 - 2014/5/22

KW - I-123-radiotracer

KW - Prolyl oligopeptidase

KW - Biodistribution

KW - Inflammation

KW - ALPHA-SYNUCLEIN

KW - MULTIPLE-SCLEROSIS

KW - PERIPHERAL-TISSUES

KW - RAT STRIATUM

KW - ENDOPEPTIDASE

KW - INHIBITION

KW - BRAIN

KW - PARKINSONS

KW - PEPTIDASES

KW - KYP-2047

KW - 317 Pharmacy

KW - 116 Chemical sciences

U2 - 10.1016/j.ejmech.2014.04.014

DO - 10.1016/j.ejmech.2014.04.014

M3 - Article

VL - 79

SP - 436

EP - 445

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

SN - 0223-5234

ER -