TY - JOUR
T1 - Synthesis, characterization and biocompatibility of guar gum-benzoic acid
AU - Le, Trung Anh
AU - Guo, Yong
AU - Zhou, Jun Nian
AU - Yan, Jiaqi
AU - Zhang, Hongbo
AU - Huynh, Tan Phat
N1 - Funding Information:
T.-A.L. acknowledges the DNMR doctoral fellowship from Åbo Akademi University. T.-P.H. would like to acknowledge the financial support from the starting fund from the Liv och Hälsa Foundation , and the Academy of Finland (Grant No. 323240 ). Y.G. and J.-N.Z. acknowledge the program of China Scholarships Council (No. 201909110009 and No. 201803170073 ). H.Z. acknowledges Academy of Finland (Grant No. 328933 ) and Sigrid Jusélius Foundation (decision no. 28002247K1 ) for financial support. Imaging/Flow cytometry was performed at the Cell Imaging and Cytometry core at Turku Bioscience Centre, which is supported by Biocenter Finland.
Publisher Copyright:
© 2021 The Author(s)
PY - 2022/1/1
Y1 - 2022/1/1
N2 - A novel chemical functionalization of guar gum (GG) by benzoic acid (BA) via nucleophilic substitution reaction in aqueous solution has been reported. BA moieties are chosen due to coordination chemistry of carboxylic acid moieties, hydrophobicity and intermolecular interaction of aromatic rings. The presence of conjugated BA on guar gum-benzoic acid (GG-BA) with grafting density of 5.5% is confirmed by 1H NMR. Amorphous GG-BA with irregular morphology has been studied by UV–Vis, FTIR, XRD, SEM, TEM, TGA, computational chemistry and contact angle measurement. GG-BA in a concentration range from 0 to 4000 μg mL−1 has good biocompatibility to mouse embryonic fibroblasts (MEF), human mammary epithelial cells (MCF-10A) after 48 and 72 h of treatment using WST-1 assay. GG-BA shows great potential for the development of biomaterials such as bioadhesives, hydrogels, and coacervates.
AB - A novel chemical functionalization of guar gum (GG) by benzoic acid (BA) via nucleophilic substitution reaction in aqueous solution has been reported. BA moieties are chosen due to coordination chemistry of carboxylic acid moieties, hydrophobicity and intermolecular interaction of aromatic rings. The presence of conjugated BA on guar gum-benzoic acid (GG-BA) with grafting density of 5.5% is confirmed by 1H NMR. Amorphous GG-BA with irregular morphology has been studied by UV–Vis, FTIR, XRD, SEM, TEM, TGA, computational chemistry and contact angle measurement. GG-BA in a concentration range from 0 to 4000 μg mL−1 has good biocompatibility to mouse embryonic fibroblasts (MEF), human mammary epithelial cells (MCF-10A) after 48 and 72 h of treatment using WST-1 assay. GG-BA shows great potential for the development of biomaterials such as bioadhesives, hydrogels, and coacervates.
KW - Benzoic acid
KW - Biocompatibility
KW - Computational chemistry
KW - Guar gum
KW - Nucleophilic substitution
KW - 116 Chemical sciences
UR - http://www.scopus.com/inward/record.url?scp=85120563811&partnerID=8YFLogxK
U2 - 10.1016/j.ijbiomac.2021.11.180
DO - 10.1016/j.ijbiomac.2021.11.180
M3 - Article
SN - 0141-8130
VL - 194
SP - 110
EP - 116
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
ER -