The Val66Met polymorphism in the BDNF gene is associated with epilepsy in fragile X syndrome

Verna Louhivuori, Maria Arvio, Pia Soronen, Virpi Oksanen, Tiina Paunio, Maija L. Castren

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Sammanfattning

The Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene may modulate the epilepsy phenotype. We investigated the impact of polymorphisms in the BDNF gene on clinical features in fragile X syndrome (FXS). In our study sample, the Met66 allele associated with epilepsy of finnish FXS men. Abnormalities in BDNF-mediated plasticity are shown in FXS and the present data suggest that the Met66 allele might predispose FXS mates to epilepsy. (C) 2009 Published by Elsevier B.V.
Originalspråkengelska
TidskriftEpilepsy Research
Volym85
Nummer1
Sidor (från-till)114-117
Antal sidor4
ISSN0920-1211
DOI
StatusPublicerad - 2009
MoE-publikationstypA1 Tidskriftsartikel-refererad

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