Therapeutic potential and metabolic impact of alternative respiratory chain enzymes

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Sammanfattning

The alternative enzymes of the respiratory chain, which are found in all the kingdoms of life, except for vertebrates, have received great interest for the treatment of disorders related to mitochondrial dysfunction. These enzymes have recently been used in cellular and animal models to understand and mitigate pathologies from mitochondrial diseases to Parkinson’s disease and cancer. The functional properties of these alternative enzymes have also helped to answer fundamental questions about the role of the respiratory chain in maintaining cellular and tissue metabolism. At the same time, the compatibility of these enzymes with mammalian metabolism has been widely characterized, and rejected on specific occasions. Although many questions remain to be answered regarding the metabolic impact of the alternative enzymes of the respiratory chain in humans, their potential as a therapeutic and research tool is starting to unravel.

Originalspråkengelska
Titel på värdpublikationMolecular Nutrition and Mitochondria : Metabolic Deficits, Whole-Diet Interventions, and Targeted Nutraceuticals
RedaktörerSergej M. Ostojic
Antal sidor23
UtgivningsortAmsterdam
FörlagElsevier
Utgivningsdatum2023
Sidor105-127
Artikelnummer4
ISBN (tryckt)978-0-323-90256-4
ISBN (elektroniskt)978-0-323-98452-2
DOI
StatusPublicerad - 2023
MoE-publikationstypA3 Del av bok eller annan forskningsbok

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© 2023 Elsevier Inc. All rights reserved.

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