TiO2-Microchip combined to mass spectrometer for mimicking phase I metabolic reactions

Teemu Nissilä, Lauri Sainiemi, Mika-Matti Karikko, Marianna Leena Kemell, Mikko Ritala, Sami Franssila, Risto Kostiainen, Raimo Ketola

Forskningsoutput: Kapitel i bok/rapport/konferenshandlingKonferensbidragVetenskapligPeer review


We have developed a microchip based system to mimic metabolic reactions of
small organic compounds. The microchip, made of silicon, contains a titanium dioxide (TiO2) covered microreactor and an electrospray ionization (ESI) tip for direct mass spectrometric (MS) analysis. Phase I metabolic reactions were mimicked
using on-chip photocatalytic TiO2-layer and an external UV-light where the TiO2-
layer catalyzed chemical reactions. The reactions of test samples were quite similar
with biochemical reactions induced by hepatocytes or cytochrome P enzymes. The
microchip can be used for fast screening of phase I metabolic reactions and speed
up the drug discovery.
Titel på värdpublikationProceedings of the 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS 2009), November 1-5, Jeju, Korea
RedaktörerTae Song Kim, Yoon-Sik Lee
Antal sidor3
FörlagChemical and Biological Microsystems Society
StatusPublicerad - 2009
MoE-publikationstypA4 Artikel i en konferenspublikation
EvenemangInternational Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS 2009) - Jeju, Sydkorea
Varaktighet: 1 nov. 20095 nov. 2009
Konferensnummer: 13


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