TiO2-Microchip combined to mass spectrometer for mimicking phase I metabolic reactions

Teemu Nissilä, Lauri Sainiemi, Mika-Matti Karikko, Marianna Leena Kemell, Mikko Ritala, Sami Franssila, Risto Kostiainen, Raimo Ketola

Forskningsoutput: Kapitel i bok/rapport/konferenshandlingKonferensbidragVetenskapligPeer review

Sammanfattning

We have developed a microchip based system to mimic metabolic reactions of
small organic compounds. The microchip, made of silicon, contains a titanium dioxide (TiO2) covered microreactor and an electrospray ionization (ESI) tip for direct mass spectrometric (MS) analysis. Phase I metabolic reactions were mimicked
using on-chip photocatalytic TiO2-layer and an external UV-light where the TiO2-
layer catalyzed chemical reactions. The reactions of test samples were quite similar
with biochemical reactions induced by hepatocytes or cytochrome P enzymes. The
microchip can be used for fast screening of phase I metabolic reactions and speed
up the drug discovery.
Originalspråkengelska
Titel på gästpublikationProceedings of the 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS 2009), November 1-5, Jeju, Korea
RedaktörerTae Song Kim, Yoon-Sik Lee
Antal sidor3
UtgivningsortJeju
FörlagChemical and Biological Microsystems Society
Utgivningsdatum2009
Sidor1922-1924
StatusPublicerad - 2009
MoE-publikationstypA4 Artikel i en konferenspublikation
EvenemangInternational Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS 2009) - Jeju, Sydkorea
Varaktighet: 1 nov 20095 nov 2009
Konferensnummer: 13

Vetenskapsgrenar

  • 116 Kemi

Citera det här