Topical tacrolimus versus corticosteroids in childhood moderate-to-severe atopic dermatitis and the impact on airway inflammation: a long-term randomized open-label study

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Childhood moderate-to-severe atopic dermatitis (AD) is often followed by development of other atopic comorbidities like asthma. This 3-year randomized open-label comparative follow-up study of 152 1-3-year-old children with moderate-to-severe AD shows no significant differences in eczema-treatment efficacy or airway inflammation/bronchial hyperresponsiviness between treatment groups (topical corticosteroids vs. tacrolimus) or between early vs. other eczema-treatment responders.Background Childhood atopic dermatitis (AD) is often followed by other atopic comorbidities such as asthma. Aim To compare the effectiveness of topical tacrolimus (TAC) and topical corticosteroids (TCSs) and their impact on airway inflammation and bronchial hyperresponsiveness in patients with paediatric AD. Methods This was a 3-year randomized open-label comparative follow-up study of 152 1-3-year-old children with moderate-to-severe AD (trial registration: EudraCT2012-002412-95). Frequent study visits including clinical examinations, laboratory investigations (total IgE, specific IgEs, blood eosinophils), skin prick and respiratory function tests to assess airway inflammation and bronchial hyperresponsiveness (exhaled nitric oxide, airway responsiveness to exercise and methacholine) were performed. Results Changes in eczema parameters at 36 months were similar in the TCS and TAC groups for mean body surface area (BSA) difference 1.4 [95% confidence interval (CI) -1.48 to 4.19); P = 0.12], mean Eczema Area and Severity Index (EASI) difference 0.2 (95% CI -1.38 to 1.82; P = 0.2), mean Investigator's Global Assessment (IGA) difference, 0.3 (95% CI -0.12 to 0.67; P = 0.12) and mean transepidermal water loss (TEWL) difference at the eczema site, -0.3 (95% CI -4.93 to 4.30; P = 0.96) and at the control site, 1.4 (95% CI -0.96 to 3.60, P = 0.19). The control-site TEWL increased more towards the end of follow-up in the TCS vs. TAC group (mean change difference -4.2, 95% CI -8.14 to -0.29; P = 0.04). No significant impact on development of airway inflammation or bronchial hyperresponsiveness occurred in early effective eczema-treatment responders vs. others ('early' vs. 'other' response was defined as the difference in treatment response to airway outcomes in BSA, EASI or IGA at 3 months). Conclusion Children with moderate-to-severe AD benefit from long-term treatment with TCS or TAC. There were no significant differences in treatment efficacy. No differences in the impact on airways occurred between early effective treatment responders vs. others.
Originalspråkengelska
TidskriftClinical and Experimental Dermatology
Volym48
Nummer6
Sidor (från-till)660-666
Antal sidor7
ISSN0307-6938
DOI
StatusPublicerad - 5 juni 2023
MoE-publikationstypA1 Tidskriftsartikel-refererad

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  • 3121 Allmänmedicin, inre medicin och annan klinisk medicin

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