Towards nucleotide prodrugs derived from 2,2-bis(hydroxymethyl)malonate and its congeners: Hydrolytic cleavage of 2-cyano-2-(hydroxymethyl)-3-methoxy-3-oxopropyl and 3-(alkylamino)-2-cyano-2-(hydroxymethyl)-3-oxopropyI protections from the internucleosidic phosphodiester and phosphorothioate linkages

P  Poijarvi; E  Maki; J  Tomperi; M  Ora; M  Oivanen; H  Lonnberg

Towards nucleotide prodrugs derived from 2,2-bis(hydroxymethyl)malonate and its congeners: Hydrolytic cleavage of 2-cyano-2-(hydroxymethyl)-3-methoxy-3-oxopropyl and 3-(alkylamino)-2-cyano-2-(hydroxymethyl)-3-oxopropyI protections from the internucleosidic phosphodiester and phosphorothioate linkages

P Poijarvi, E Maki, J Tomperi, M Ora, M Oivanen, H Lonnberg

Avdelningen för kemi

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

Originalspråk	engelska
Tidskrift	Helvetica chimica acta
Volym	2002/85
Sidor (från-till)	1869-1876
Antal sidor	8
ISSN	0018-019X
Status	Publicerad - 2002
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

Vetenskapsgrenar

116 Kemi

Citera det här

Poijarvi, P., Maki, E., Tomperi, J., Ora, M., Oivanen, M., & Lonnberg, H. (2002). Towards nucleotide prodrugs derived from 2,2-bis(hydroxymethyl)malonate and its congeners: Hydrolytic cleavage of 2-cyano-2-(hydroxymethyl)-3-methoxy-3-oxopropyl and 3-(alkylamino)-2-cyano-2-(hydroxymethyl)-3-oxopropyI protections from the internucleosidic phosphodiester and phosphorothioate linkages. Helvetica chimica acta, 2002/85, 1869-1876.

Poijarvi, P ; Maki, E ; Tomperi, J et al. / Towards nucleotide prodrugs derived from 2,2-bis(hydroxymethyl)malonate and its congeners: Hydrolytic cleavage of 2-cyano-2-(hydroxymethyl)-3-methoxy-3-oxopropyl and 3-(alkylamino)-2-cyano-2-(hydroxymethyl)-3-oxopropyI protections from the internucleosidic phosphodiester and phosphorothioate linkages. I: Helvetica chimica acta. 2002 ; Vol. 2002/85. s. 1869-1876.

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title = "Towards nucleotide prodrugs derived from 2,2-bis(hydroxymethyl)malonate and its congeners: Hydrolytic cleavage of 2-cyano-2-(hydroxymethyl)-3-methoxy-3-oxopropyl and 3-(alkylamino)-2-cyano-2-(hydroxymethyl)-3-oxopropyI protections from the internucleosidic phosphodiester and phosphorothioate linkages",

keywords = "SOLID-PHASE SYNTHESIS, PROOLIGONUCLEOTIDE APPROACH, DELIVERY, OLIGONUCLEOTIDES, DERIVATIVES, STABILITY, CELLS, MONOPHOSPHATES, STRATEGY, 116 Chemical sciences",

author = "P Poijarvi and E Maki and J Tomperi and M Ora and M Oivanen and H Lonnberg",

year = "2002",

language = "English",

volume = "2002/85",

pages = "1869--1876",

journal = "Helvetica chimica acta",

issn = "0018-019X",

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Poijarvi, P, Maki, E, Tomperi, J, Ora, M, Oivanen, M & Lonnberg, H 2002, 'Towards nucleotide prodrugs derived from 2,2-bis(hydroxymethyl)malonate and its congeners: Hydrolytic cleavage of 2-cyano-2-(hydroxymethyl)-3-methoxy-3-oxopropyl and 3-(alkylamino)-2-cyano-2-(hydroxymethyl)-3-oxopropyI protections from the internucleosidic phosphodiester and phosphorothioate linkages', Helvetica chimica acta, vol. 2002/85, s. 1869-1876.

Towards nucleotide prodrugs derived from 2,2-bis(hydroxymethyl)malonate and its congeners: Hydrolytic cleavage of 2-cyano-2-(hydroxymethyl)-3-methoxy-3-oxopropyl and 3-(alkylamino)-2-cyano-2-(hydroxymethyl)-3-oxopropyI protections from the internucleosidic phosphodiester and phosphorothioate linkages. / Poijarvi, P ; Maki, E ; Tomperi, J et al.

I: Helvetica chimica acta, Vol. 2002/85, 2002, s. 1869-1876.

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

TY - JOUR

T1 - Towards nucleotide prodrugs derived from 2,2-bis(hydroxymethyl)malonate and its congeners: Hydrolytic cleavage of 2-cyano-2-(hydroxymethyl)-3-methoxy-3-oxopropyl and 3-(alkylamino)-2-cyano-2-(hydroxymethyl)-3-oxopropyI protections from the internucleosidic phosphodiester and phosphorothioate linkages

AU - Poijarvi, P

AU - Maki, E

AU - Tomperi, J

AU - Ora, M

AU - Oivanen, M

AU - Lonnberg, H

PY - 2002

Y1 - 2002

KW - SOLID-PHASE SYNTHESIS

KW - PROOLIGONUCLEOTIDE APPROACH

KW - DELIVERY

KW - OLIGONUCLEOTIDES

KW - DERIVATIVES

KW - STABILITY

KW - CELLS

KW - MONOPHOSPHATES

KW - STRATEGY

KW - 116 Chemical sciences

M3 - Article

VL - 2002/85

SP - 1869

EP - 1876

JO - Helvetica chimica acta

JF - Helvetica chimica acta

SN - 0018-019X

ER -

Poijarvi P, Maki E, Tomperi J, Ora M, Oivanen M, Lonnberg H. Towards nucleotide prodrugs derived from 2,2-bis(hydroxymethyl)malonate and its congeners: Hydrolytic cleavage of 2-cyano-2-(hydroxymethyl)-3-methoxy-3-oxopropyl and 3-(alkylamino)-2-cyano-2-(hydroxymethyl)-3-oxopropyI protections from the internucleosidic phosphodiester and phosphorothioate linkages. Helvetica chimica acta. 2002;2002/85:1869-1876.