Tracting the neural basis of music

Deficient structural connectivity underlying acquired amusia

Aleksi J. Sihvonen, Pablo Ripolles, Teppo Särkämö, Vera Leo, Antoni Rodriguez-Fornells, Jani Saunavaara, Riitta Parkkola, Seppo Soinila

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Sammanfattning

Acquired amusia provides a unique opportunity to investigate the fundamental neural architectures of musical processing due to the transition from a functioning to defective music processing system. Yet, the white matter (WM) deficits in amusia remain systematically unexplored. To evaluate which WM structures form the neural basis for acquired amusia and its recovery, we studied 42 stroke patients longitudinally at acute, 3-month, and 6-month post-stroke stages using DTI [tract-based spatial statistics (TBSS) and deterministic tractography (DT)] and the Scale and Rhythm subtests of the Montreal Battery of Evaluation of Amusia (MBEA). Non-recovered amusia was associated with structural damage and subsequent degeneration in multiple WM tracts including the right inferior fronto-occipital fasciculus (IFOF), arcuate fasciculus (AF), inferior longitudinal fasciculus (ILF), uncinate fasciculus (UF), and frontal aslant tract (FAT), as well as in the corpus callosum (CC) and its posterior part (tapetum). In a linear regression analysis, the volume of the right IFOF was the main predictor of MBEA performance across time. Overall, our results provide a comprehensive picture of the large-scale deficits in intra- and interhemispheric structural connectivity underlying amusia, and conversely highlight which pathways are crucial for normal music perception.
Originalspråkengelska
TidskriftCortex
Volym97
Sidor (från-till)255-273
Antal sidor19
ISSN0010-9452
DOI
StatusPublicerad - 8 dec 2017
MoE-publikationstypA1 Tidskriftsartikel-refererad

Vetenskapsgrenar

  • 3124 Neurologi och psykiatri
  • 515 Psykologi

Citera det här

Sihvonen, Aleksi J. ; Ripolles, Pablo ; Särkämö, Teppo ; Leo, Vera ; Rodriguez-Fornells, Antoni ; Saunavaara, Jani ; Parkkola, Riitta ; Soinila, Seppo . / Tracting the neural basis of music : Deficient structural connectivity underlying acquired amusia. I: Cortex. 2017 ; Vol. 97. s. 255-273.
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abstract = "Acquired amusia provides a unique opportunity to investigate the fundamental neural architectures of musical processing due to the transition from a functioning to defective music processing system. Yet, the white matter (WM) deficits in amusia remain systematically unexplored. To evaluate which WM structures form the neural basis for acquired amusia and its recovery, we studied 42 stroke patients longitudinally at acute, 3-month, and 6-month post-stroke stages using DTI [tract-based spatial statistics (TBSS) and deterministic tractography (DT)] and the Scale and Rhythm subtests of the Montreal Battery of Evaluation of Amusia (MBEA). Non-recovered amusia was associated with structural damage and subsequent degeneration in multiple WM tracts including the right inferior fronto-occipital fasciculus (IFOF), arcuate fasciculus (AF), inferior longitudinal fasciculus (ILF), uncinate fasciculus (UF), and frontal aslant tract (FAT), as well as in the corpus callosum (CC) and its posterior part (tapetum). In a linear regression analysis, the volume of the right IFOF was the main predictor of MBEA performance across time. Overall, our results provide a comprehensive picture of the large-scale deficits in intra- and interhemispheric structural connectivity underlying amusia, and conversely highlight which pathways are crucial for normal music perception.",
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author = "Sihvonen, {Aleksi J.} and Pablo Ripolles and Teppo S{\"a}rk{\"a}m{\"o} and Vera Leo and Antoni Rodriguez-Fornells and Jani Saunavaara and Riitta Parkkola and Seppo Soinila",
year = "2017",
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Tracting the neural basis of music : Deficient structural connectivity underlying acquired amusia. / Sihvonen, Aleksi J.; Ripolles, Pablo; Särkämö, Teppo ; Leo, Vera; Rodriguez-Fornells, Antoni; Saunavaara, Jani; Parkkola, Riitta; Soinila, Seppo .

I: Cortex, Vol. 97, 08.12.2017, s. 255-273.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

TY - JOUR

T1 - Tracting the neural basis of music

T2 - Deficient structural connectivity underlying acquired amusia

AU - Sihvonen, Aleksi J.

AU - Ripolles, Pablo

AU - Särkämö, Teppo

AU - Leo, Vera

AU - Rodriguez-Fornells, Antoni

AU - Saunavaara, Jani

AU - Parkkola, Riitta

AU - Soinila, Seppo

PY - 2017/12/8

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N2 - Acquired amusia provides a unique opportunity to investigate the fundamental neural architectures of musical processing due to the transition from a functioning to defective music processing system. Yet, the white matter (WM) deficits in amusia remain systematically unexplored. To evaluate which WM structures form the neural basis for acquired amusia and its recovery, we studied 42 stroke patients longitudinally at acute, 3-month, and 6-month post-stroke stages using DTI [tract-based spatial statistics (TBSS) and deterministic tractography (DT)] and the Scale and Rhythm subtests of the Montreal Battery of Evaluation of Amusia (MBEA). Non-recovered amusia was associated with structural damage and subsequent degeneration in multiple WM tracts including the right inferior fronto-occipital fasciculus (IFOF), arcuate fasciculus (AF), inferior longitudinal fasciculus (ILF), uncinate fasciculus (UF), and frontal aslant tract (FAT), as well as in the corpus callosum (CC) and its posterior part (tapetum). In a linear regression analysis, the volume of the right IFOF was the main predictor of MBEA performance across time. Overall, our results provide a comprehensive picture of the large-scale deficits in intra- and interhemispheric structural connectivity underlying amusia, and conversely highlight which pathways are crucial for normal music perception.

AB - Acquired amusia provides a unique opportunity to investigate the fundamental neural architectures of musical processing due to the transition from a functioning to defective music processing system. Yet, the white matter (WM) deficits in amusia remain systematically unexplored. To evaluate which WM structures form the neural basis for acquired amusia and its recovery, we studied 42 stroke patients longitudinally at acute, 3-month, and 6-month post-stroke stages using DTI [tract-based spatial statistics (TBSS) and deterministic tractography (DT)] and the Scale and Rhythm subtests of the Montreal Battery of Evaluation of Amusia (MBEA). Non-recovered amusia was associated with structural damage and subsequent degeneration in multiple WM tracts including the right inferior fronto-occipital fasciculus (IFOF), arcuate fasciculus (AF), inferior longitudinal fasciculus (ILF), uncinate fasciculus (UF), and frontal aslant tract (FAT), as well as in the corpus callosum (CC) and its posterior part (tapetum). In a linear regression analysis, the volume of the right IFOF was the main predictor of MBEA performance across time. Overall, our results provide a comprehensive picture of the large-scale deficits in intra- and interhemispheric structural connectivity underlying amusia, and conversely highlight which pathways are crucial for normal music perception.

KW - 3124 Neurology and psychiatry

KW - 515 Psychology

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KW - MUSIC

KW - STROKE

KW - TRACTOGRAPHY

KW - Tract-based spatial statistics

KW - FUNCTIONAL MRI EVIDENCE

KW - CONGENITAL AMUSIA

KW - WHITE-MATTER

KW - AUDITORY-CORTEX

KW - ARCUATE FASCICULUS

KW - HUMAN BRAIN

KW - UNCINATE FASCICULUS

KW - DTI tractography

KW - CORPUS-CALLOSUM

KW - anatomic dissection

U2 - 10.1016/j.cortex.2017.09.028

DO - 10.1016/j.cortex.2017.09.028

M3 - Article

VL - 97

SP - 255

EP - 273

JO - Cortex

JF - Cortex

SN - 0010-9452

ER -